Title: Alendronate Sodium in Osteoarthritis: Effects on Lipid Profile, Circulating Leptin and the Clinical Activity

Authors: Sinaa Abdul Amir Kadhim, Haidar Mahdi Jawad, Sami Salman Shihab

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i3.109

Abstract

Objective: Osteoarthritis (OA) is a most common arthritic disease and responsible for more of disability in all world. OA affects all joint and characterized by degredation of cartilage, subchondral bone turnover and osteophytes formation.                                           

Aim of the study: To evaluate the effectiveness of alendronate sodium (ALN) on disease activity and physical function, evaluate the lipid profile and study the impact of ALN on circulating leptin marker and myeloperoxidase (MPO) and to determine its effectiveness in slowing progression of disease.

Patients and methods:116 OA patients over 45 years old with X-ray grade II and more of Kellgren and Lawrence grading were enrolled in our study. Base line assessment was done, Kellgren and Lawrence X-ray grading, WOMAC scoring, body mass index and the lipid profil with enzyme-linked immunosorbent assay (ELISA) analysis of serum leptin and MPO. They were instructed to take ALN 10 mg daily. Reassessment was done after 3 months. 

Results: A significant  symptomatic improvement in WOMAC  scoring (pain, stiffness) were observed associated with significant reduction in serum leptin and  no significant reduction in MPO. A nonsignificantchanges in lipid profile, joint space width and function were also reported.

Conclusion: ALN in patients with OA has clinical efficacy in reducing suffering especially pain probably through inhibition of leptin with no significant joint structural improvement, and may help delay and prevent further disease progression probably through inhibition of leptinactivity.

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Corresponding Author

Sinaa Abdul Amir Kadhim

Ass. Prof., Pharmacology Department

College of Medicine, University of Al-Qadisiyah Iraq

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