Title: Successful Treatment of Chronic Osteomyelitis of Calcaneum by Intravenous Linezolid

Authors: Dr Deepak Bhosle, Dr Jyoti Bobde, Dr Rajesh Kadam, Dr Abhijeet Bhagat,  Dr Asif Sayyed, Dr Vasundhara Bhople, Dr Aleemuddin Shaikh, Dr Huzaif Shaikh, Dr Ayman Ali Khan, Dr Zubair Quazi

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i3.62

Abstract

Osteomyelitis in children is a potentially serious condition and have potential for lifelong disability and morbidity. The early diagnosis and appropriate treatment is critically important. The common causative organisms for chronic osteomyelitis are staphylococcus aureus, streptococci, H influenza and salmonella. In children with sickle cell anaemia the most common organisms are salmonella. The collection of appropriate sample like discharging pus or even bone sampling for microbiological and pathological examination may allow choosing the most effective antibiotics. Methicillin resistant S.aureus which earlier used to be considered as nosocomial infection is increasingly being identified in community acquired infections. We present here a case of acute osteomyelitis caused by methicillin resistant staphylococcus aureus. The patient was a 8 year old male child with no significant past medical history was admitted with complaints of heel pain and inability to bear weight on affected limb since 4-6 weeks. Patient earlier took treatment from local physician who prescribed some oral medicine. There was no improvement in the pain and at the time of presentation to our institute the patient had more definitive signs of infection including fever and local tenderness and a discharging sinus. An MRI was done which revealed features of osteomyelitis in the form of sequester and soft tissue gas. Since the history was that of more than 1 month a diagnosis of chronic osteomyelitis was made and the discharging pus was sent for microbiological examination which showed growth of methicillin resistant staphylococcus aureus sensitive to linezolid. Patient was successfully treated with linezolide in appropriate doses.

Our case emphasise the importance of proper investigations (Imaging, microbiological and pathological examinations) and treatment with appropriate antibiotics in patients suspected to be having osteomyelitis.

Keywords: Chronic osteomyelitis, Methicillin Resistant Staphylococcus aureus, Linezolid, Computed Tomography.

References

1.      Fritz JM, McDonald JR. Osteomyelitis: Approach to Diagnosis and Treatment. The Physician and sportsmedicine. 2008;36(1):nihpa116823.

2.      Roesgen M, Hierholzer G, Hax PM. Post-traumatic osteomyelitis. Pathophysiolog and management. Arch Orthop Trauma Surg. 1989;108(1):1-9.

3.      Ikpeme I, Ngim N, Ikpeme A. Diagnosis and treatment of pyogenic bone infections. African Health Sciences.2010;10(1):82-88.

4.      Wilensky AO. The joint complications of acute osteomyelitis or acute epiphysitis: and the principles underlying their treatm-ent. Annals of Surgery. 1927;86(5):737-746.

5.      Rao N, Ziran BH, Lipsky BA. Treating osteomyelitis: antibiotics and surgeryPlast Reconstr Surg. 2011 Jan;127 Suppl 1:177 S-187S.

6.      Pineda C, Espinosa R, Pena A. Radiographic Imaging in Osteomyelitis: The Role of Plain Radiography, Computed Tomography, Ultrasonography, Magnetic Resonance Imaging, and Scintigraphy. Seminars in Plastic Surgery. 2009;23 (2):80-89.

7.      Mujoomdar M, Russell E, Dionne F, et al. Optimizing Health System Use of Medical Isotopes and Other Imaging Modalities [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2012. APPENDIX 2.5, Diagnosis of Acute Osteomyelitis. Available from: https://www.ncbi.nlm.nih.gov/books/NBK174851/

8.      Wang EH, Simpson S, Bennet GC. Osteomyelitis of the calcaneum. J Bone Joint Surg Br. 1992;74(6):906–9.

9.      Malcius D, Jonkus M, Kuprionis G, Maleckas A, Monastyreckiene E, Uktveris R, et al. The accuracy of different imaging techniques in diagnosis of acute hematoge-nous osteomyelitis. Medicina (Kaunas) 2009;45:624–31.

10.  Rayner CR, Baddour LM, Birmingham MC, Norden C, Meagher AK, Schentag JJ.Linezolid in the treatment of osteomyelitis: results of compassionate useexperience. Infection. 2004 Feb;32 (1):8-14.

Corresponding Author

Dr Asif Sayyed

Chief Resident, Department of Pharmacology

MGM Medical College, Aurangabad, Maharashtra,India