Title: Study on Vitamin D Level and Micro Vascular Complications of Type 2 Diabetes Mellitus
Authors: Dr P. K. Dash, MBBS, MD, Dr S. K. Jangid, MBBS, MD
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.63
Vitamin D mainly regulates calcium and phosphate metabolism, its deficiency may also be involved in the aetiopathogenesis of carcinomas, autoimmune diseases, infections, respiratory and cardiac diseases. A total of 80 cases were studied. Among the 80 patients with diabetes, 34 were female and 46 were male with a mean age of 46.9 ± 8.9 years along with 20 age and sex matched healthy controls. The vitamin D status of patients with diabetes should be considered during their regular follow-up, and supplementation should be provided to those at risk of deficiency. Key words: 25-OH Vitamin D, Type-2 DM and Microvascular complications. 1. Adorini L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 2008; 4: 404–12. 2. Janssens W, Lehouck A, Carremans C, Bouillon R, Mathieu C, Decramer M. Vitamin D beyond bones in chronic obstructive pulmonary disease: time to act. Am J Respir Crit Care Med 2009; 179:630–6. doi: 10.1164/rccm.200810-1576PP. Epub 2009 Jan 22. 3. Kendrick J, Targher G, Smits G, Chonchol M. 25-Hydroxyvitamin D deficiency is independently associated with cardio vascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis 2009; 205: 255–60. 4. Mohr SB. A brief history of vitamin D and cancer prevention. Ann Epidemiol 2009; 19: 79–83. 5. Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 2005; 26: 662–87. 6. Staud R. Vitamin D: more than just affecting calcium and bone. Curr Rheumatol Rep 2005; 7: 356–64. 7. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013;36:260–6. 8. Cangoz S, Chang YY, Chempakaseril SJ, Guduru RC, Huynh LM, John JS, et al. Vitamin D and type 2 diabetes mellitus. J Clin Pharm Ther. 2013;38:81–4. 9. Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia. 1995;38:1239–45. 10. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E. Serum 25-hydroxy vitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract. 1995;27:181–8. 11. Prevention and management of osteoporosis. World Health Organ Tech Rep Ser 2003;921:1‑164. 12. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: 2813–8. 13. Danescu LG, Levy S, Levy J. Vitamin D & diabetes mellitus. Endocrine 2009; 35: 11-7. 14. Pietschmann P, Schernthaner G, Woloszczuk W. Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 1988; 31: 892–5. 15. Orwoll E, Nielson CM, Marshall LM, Lambert L, Holton KF, Hoffman AR et al. Vitamin D deficiency in older men. J Clin Endocrinol Metab 2009; 94: 1214–22. doi: 10.1210/jc.2008-1784. Epub 2009 Jan 27. 16. Lee JH, O’Keefe JH, Bell D, Hensrud DD, Holick MF. Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008; 52: 1949–56. doi: 10.1016/j.jacc.2008.08.050. 17. Lips P. Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol 2007; 103: 620–5. 18. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266–81. 19. Gedik O, Akalin S. Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986; 29: 142–5. 20. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care 2007; 30: 980–6. 21. Albert DM, Scheef EA,Wang S, Mehraein F, Darjatmoko SR, Sorenson CM et al. Calcitriol is a potent inhibitor of retinal neovascularization. Invest Ophthalmol Vis Sci 2007; 48: 2327–34. 22. Klein R, Klein BE, Moss SE. Relation of glycemic control to diabetic microvascular complications in diabetes mellitus. Ann Intern Med 1996; 124: 90–6. 23. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ 1998; 317: 703–13. 24. Kristal-Boneh E, Froom P, Harari G, Ribak J. Association of calcitriol and blood pressure in normotensive men. Hypertension 1997; 30:1289–94. 25. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002; 110: 229–38. 26. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W et al. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab 2005; 288: E125–32. 27. Zehnder D, Quinkler M, Eardley KS, Bland R, Lepenies J, Hughes SV et al. Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation. Kidney Int 2008; 74:1343–53. doi: 10.1038/ki.2008.453. Epub 2008 Sep 10. 28. Agarwal R, Acharya M, Tian J, Hippensteel RL, Melnick JZ, Qiu P et al. Antiproteinuric effect of oral paricalcitol in chronic kidney disease. Kidney Int 2005; 68: 2823–8. 29. Fiscella KA, Winters PC, Ogedegbe G. Vitamin D and racial disparity in albuminuria: NHANES 2001–2006.Am J Hypertens 2011; 24: 1114–20. 30. Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes? Diabet Med 2012; 29: 43–9. doi: 10.1111/j.1464-5491.2011.03510.x.Abstract
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