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Category: Volume 4 Issue 02 Feb 2016
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Title: The Effect of Omega-3 Therapy on Induced Hyperacidity

Authors: Hader Ibrahim Sakr, Mohamed Mansour Khalifa, Mohamed Al Sayed Saleh, Laila Ahmed Rashed, Akef Abdelhalim Khowailed

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i2.25

Abstract

Gastric hyperacidity is a serious health problem of global concern. This work was conducted to study the effect of chronic administration of omega-3 polyunsaturated fatty acids (PUFA) on HCl secretion and stress-induced ulcer in male albino rats. Study groups included 24 rats divided into 2 main groups with 12 rats in each as follows: pyloric ligation group (A) and water immersion-induced gastric ulceration group (B). Each subgroup contained 6 rats. Among the parameters estimated in the studied groups were: free and total HCL secretion in group A, and ulcer score, ulcer index, percentage ulcer protection, histology of the stomach, eNOS enzyme activity, COX-2 enzyme activity, glutathione reductase enzyme gene expression, CCK gene expression and proton pump (H+/K+ ATPase) gene expression in group B.

RESULTS showed significant decrease in free and total acidity, ulcer score and index, COX-2 enzyme activity and Proton pump (H+/K+ ATPase) gene expression among ω-3 fed rats compared with the results of the control group. On the other hand significant elevation was observed in the percentage ulcer protection, eNOS enzyme activity, glutathione reductase gene expression and CCK gene expression among omega-3 fed rats compared to control group.

CONCLUSION, the present study revealed a protective effect of omega-3 PUFA on stress-induced gastric ulceration.

Key words: Gastric hyperacidity, HCl, H+/K+ ATPase pump, H2-receptor blockers, omega-3 PUFA.

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Corresponding Author

Hader Ibrahim Sakr, MD

Department of Medical Physiology, Kasr Al Ainy Faculty of Medicine

Cairo University, Cairo Egypt

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