Title: Bilateral Multicentric Metachronous Benign Phylloides Tumor: A Rare Presentation
Authors: Varsha Pandey, V. Sudarshan, Naveen K. Verma, Karan S. Chandrakar, Rajni P. Verma
DOI: http://dx.doi.org/10.18535/jmscr/v4i2.23
Phylloides tumor is rare stromal tumor of breast. It is common in median age group. It is known for its presentation as unilateral huge mass. However, the diagnosis of phylloides tumor can be neither made or nor ruled out by the size alone. Bilateral phylloides tumors are distinctly uncommon. Most of them are malignant and metachronous. We present a rare case of bilateral multicentric benign metachronous phylloides tumor of breast in a young female of 20 years of age. Key words: Benign, bilateral, metachronous, multicentric, phylloides tumor 1. Tse GM, Niu Y, Shi HJ. Phyllodes tumor of the breast. an update. Breast Cancer. May 12. [Epub ahead of print], 2009. (PMID: 19434472). 2. Keelan PA, Myers JL, Wold, et al. Phylloides tumor: Clinicopathologic review of 60 patients and flow cytometric analysis in 30 patients. Hum Pathol. 1992;23:1048-54. 3. Bernstein L, Deapen D, Ross RK. The descriptive epidemiology of malignant cystosarcoma phylloidestumors of breast. Cancer 1993, 71:3020- 3024. 4. Azzopardi JG. Problems in breast pathology. In Benington JL, Major problems in pathology. Philadephia 1979, W.B. Saunders. 5. Fiks A. Cystosarcoma phylloides of the mammary gland. Muller’s tumor. For the 180th birthday of Johannes Muller. Virchow’s Arch [A] 1981, 392: 1-6. 6. Beb HSSOUNA j, Damak T, Gamoudi A etal. Phyllodes tumors of the breast A case series of 106 patients. Am J surg. 2006;192:141-7. 7. Finocchi L, Covarelli P, Rulli A, Servoli A, Noya G. Bilateral phylloid cystosarcoma of the breast: a case report and review of the literature. Chir Ital. 2008; 60(6): 867-872. (PMID: 19256279). 8. Mrad K, Driss M, Maalej M, Romdhane KB. Bilateral cystosarcoma phyllodes of the breast: a case report of malignant form with contralateral benign form. Ann Diagn Pathol. 2000; 4(6):370-3722. (PMID: 11149968). 9. Ezeome ER, Okafor OC, Nwajiobi CE, Osuagwu CC. Bilateral benign phyllodes tumor in a nulliparous woman: a case report and review of literature. Niger J Clin Pract. 2007; 10(1):66-69.( PMID: 17668718). 10. Marti J.L., K. Hiotis K. Excision of 13 phyllodes bilateral breast tumors in one patient. J Clin Oncol 26: 2008 (May 20 suppl; abstr 11584) 11. Konstantakos AK, Graham DJ. Cystosarcoma phyllodes tumors in men. Am Surg. 2003; 69(9): 808-811,. (PMID: 14509333) 12. Hawkins RE, Schofield JB, Fisher C, Wiltshaw E, McKinna JA. The clinical and histologic criteria that predical metastases from cystosarcoma phyllodes. Cancer. 1992; 69(1):141-147. (PMID: 1309302). 13. Moffat CJC, Pinder SE, Dixon AR, et al. Phylloides tumors of breast : a clinicopathologic review of 32 cases. Histopathology 1995; 27:205-218. 14. Bellocq J, Magro G. Fibroepithelial tumors. In: Tavassoli F, Devilee P, editors. World Health Organization classification o f tumors. Pathology and genetics of tumors of the breast and female genital organs. Lyon: IARC Press; 2003; 99–103. 15. Zurrida S, Bartoli C, Galimberti V, Squicciarini P, Delledonne V, Veronesi P, Bono A, de Palo G, Salvadori B. Which theraphy for unexpected phylloides tumor of the breast. Eur J Cancer. 1992; 28: 654-657. (PMID: 1317204) 16. Rajan PB, Cronar ML, Rosen PP: Cystosarcoma phyllodes in adolescent girls and young women: a study of 45 patients. Am J Surg Pathol. 1988; 22(1): 64-69. (PMID: 9422317) 17. Chaney AW, Pollack A, McNeese MD, Zagars GK, Pisters PW, Pollock RE, Hunt KK. Primary treatment of cystosarcoma pyllodes of the breast. Cancer. 2000; 89: 1502-1511. (PMID: 11013364). 18. Ben Hassouna J, Damak T, Gamoudi A, Chargui R, Khomsi F, Mahjoub S, Slimene M, Ben Dhiab T, Hechiche M, Boussen H, Rahal K. Phyllodes tumors of the breast: a case series of 106 patients. Am J Surg. 2006; 192: 141-147. (PMID: 16860620). 19. Macdonald OK, Lee CM, Tward JD, Chappel CD, Gaffney DK. Malignant phyllodes tumor of the female breast. Cance r. 2006; 107: 2127-2133. (PMID: 16998937). 20. C heng SP, Chang YC, Liu TP, Lee JJ, Tzen CY, Liu CL. Phyllodes tumor of the breast: the challenge persists. Word J Surg 2006; 30: 1414-1421. (PMID: 16865317). 21. Karim RZ, Gerega SK, Yang YH, Spillane A, Carmalt H, Scolyer RA, Lee CS. Phyllodes tumors of the breast: a clinicopathological analysis of 65 cases from a single institution. Breast. 2009; 18(3):165-70. (PMID:19329316).Abstract
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