Title: Study of Serum IP-10 Level as a Predictor for Non Alcoholic Steatohepatitis (NASH) In Diabetic and Non Diabetic Patients

Authors: El Said Ibrahim,  Doaa Hashad, Perihan Salem, Youssra Abo Elfotoh

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i2.12

Abstract

Non alcoholic liver disease (NAFLD) is a public health problem with high prevalence, high level of disability associated and high cost for the health system. Non alcoholic steato hepatitis (NASH) is among its spectrum where histopathological changes similar to those in alcoholic hepatitis were observed. Interferon gamma-induced protein 10 (IP-10) is secreted in response to proinflammatory cytokines where it plays an important role in directing migration of cells, thus, function to regulate cell trafficking. This work aimed to study the significance of serum IP-10 level as a marker for NASH in diabetic and non-diabetic patients. Also, to correlate its level in the studied groups with clinical and laboratory findings.

Key words: NAFLD, NASH, cytokines, chemokines, IP-10, type II DM.

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Corresponding Author

Perihan Salem

Hepatobiliary Unite, Internal Medicine Department

Alexandria University