Title: Status of Serum Leptin and Lipid Profile in Newly Diagnosed Psoriasis Patients: A Case Control Study
Authors: Ghalaut VS, Sarkar M, Dayal S, Gupta G, Samanta S, Rajju T
DOI: http://dx.doi.org/10.18535/jmscr/v4i3.41
Objective: Psoriasis is an autoimmune chronic inflammatory disease involving the skin and mucous membranes. Besides the autoimmune and genetic factors many stressful physiologic, psychological events and environmental factors play an important role in disease etiopathogenesis. Leptin, an adipocyte-derived hormone, plays a role in immune responses and may be involved in the pathogenesis of psoriasis. Psoriasis is associated with variety of lipid profile disorders. So, we performed this study to determine serum leptin levels and lipid profile in psoriasis patients. Material and methods: We conducted a prospective case control study from February 2014 to April 2015 on 30 patients of psoriasis and 30 age and sex match healthy control subjects. We measured serum leptin level by ELISA technique and lipid profile by enzymatic method. Results: Serum leptin and lipid profile of total 60 subjects, 30 patients of psorisis and 30 age and sex match healthy volunteers were analysed in this study. Leptin level was found to be significantly higher in psorisis group as compared to healthy volunteers (p <0.05).We also found significantly higher leptin level in psoriasis patients with higher PASI (Psoriasis Area and Severity Index) score (> 15) compared to low PASI score (< 15).Among lipid profile parameters TC, TG, LDL-C and VLDL-C were significantly higher in psoriasis group compared to healthy control (p<0.05). HDL-C level was significantly lower in psoriasis patients compared to healthy controls (p <0.05). Conclusion: Psoriasis is associated with hyperleptinemia. Higher leptin level was found in patients with higher PASI score. Thus, it may have role in the pathogenesis or severity of psoriasis. Dyslipidemia is also common in psoriasis. We recommend early monitoring of both leptin and lipid profile in these patients to prevent development of metabolic syndrome and long term cardiovascular events. We suggest more large scale studies in psoriasis patients to establish it. 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