Title: A Serological Study of Blood Borne Viral Hepatitis Cases Attending IIMS & R, Lucknow

Authors: Karuna Dubey*, Shabnam Parveen, Dr Sanjeev Sahai

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i3.35

Abstract

Context:Acute   vira hepatitis   (AVH)   is    major   public   health   problem   and   is   an important cause of morbidity and mortality.

Aim:To study the prevalence of viral Hepatitis B and Hepatitis C cases in patients attending IIM&R,Lucknow,U.P.

Material&Method: Blood sampleand clinical information wacollectefrom cases of over a 6 month period (1st January 2015 to 30th June 2015)..Samples were tested for Hepatitis B surface antigen, anti-HCV total antibodies.

Statistical Analysis Used:Fisher’s exact test was useand a  P<0.05 waconsidered to be statistically significant.

ResultsThe prevalence rate was found to be 4.5% in HBand 2.5% for HCV. Out of 1434 patients 66 were Hepatitis B positive and 35 were Hepatitis C virus. 57.6% of the patients of Hepatitis B and 31.4%of hepatitis C were males. On comparing both HBand HCV positive viral infections, statistically significant values(p≤ 0.05) were found inmales. About three fourth(76.9%) of the patients of hepatitis B and 62.9% of HCV were found to be literate and belonged to loweand middle socio-economic status having poor hygiene. Statistically significant values  were  observed  in  low  socio-economic  status  (p≤.003) ,  literacy  level    (p≤  0.01) ,  serum  bilirubin  (p=0.005)  and  alkaline  phosphate (p=0.002)between Hepatitis B and C patients was observed. The resulsfELISA teswere 100whilfor Rapid cartest  it  was  95%  only  

ConclusionPreventive measures should include heal thducation regarding parentral transmission of infections tringent blood banking laws need to be introduced and use of disposablsyringes/needles should bmademandatoryReuse of needles, shaving kits and razor blades should be discouaged. Universal immunization of all infants is desirable to decrease the carrier pool and it is inferred from the present study that Hepatitis Bimmunization should bginat birth to have greater impact.

Keywords: Viral hepatitis, hepatitis B, hepatitis C, Enzyme linked immunoassay

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Corresponding Author

Dr Karuna Dubey

Department of Microbiology

Integral Institute of Medical Sciences and Research, Lucknow, India

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