Title: The Comparative Study of Homocysteine, Folate and Cobalamine Level in Hyperthyroid Women and Normal Healthy Women

Authors: Choudhary Nitu, Kumar Rohitash, Dr Vyas R. K.

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i3.23

Abstract

 Background: Thyroid disorders are among the most common endocrine disorders in India.  The prevalence and pattern of the thyroid disorders depends on age, sex, geographical factors, food habits and on iodine intake.(1) A Hospital based case-control study was planned, including 50 patients of clinically proven hyperthyroid  disease women patient (Case) and 50 age and sex matched controls attending medicine OPD and microbiology department  of S. P. Medical College and Associated Group of Hospitals, Bikaner for study of Homocysteine, Folate and Cobalamine levels.

Method: Plasma Homocysteine, Folate and Cobalamine levels were measured by HPLC (High Performance Liquid Chromatography) Method in clinical Biochemistry laboratory, S. P. Medical College, Bikaner.

Results: A statically significant decreased concentration of plasma homocysteine was recorded in hyperthyroid patients as compared to Controls (p-value 0.0001). The serum vitamin B9 (folic acid) concentration was found to be decreased significantly in hyperthyroid female patients as compared to Controls (p-value 0.0001). A statically   significantly   increased  concentration   of serum  cobalamine  ( Vit B12) was  found  in hyperthyroid  patients  as compared to normal  control  female  subject (p-value  0.0001).

Conclusion: Estimation of Serum Homocysteine, Folate and Cobalamine level is simple, reliable, economic and sensitive and it can be used in the proper management of developing new therapeutic strategies in treatment of hyperthyroid women patients.

Keywords: Homocysteine, Folate, Cobalamine, Hyperthyroidism.

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Corresponding Author

Rohitash Kumar

M.Sc. (Medicine) Biochemistry, Senior Demonstrator, Department of Biochemistry,

SMS Medical College, Jaipur, Rajasthan (INDIA)

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