Role of Previous Adenovirus Infection and Its Association with IFN-α in Occurrence of Celiac Disease in Iraqi Patients

Title: Role of Previous Adenovirus Infection and Its Association with IFN-α in Occurrence of Celiac Disease in Iraqi Patients

Authors: Hashim Raheem Tarish, Wasan Sami Hameed, Raad Jasim Abdul-Mehdi, Hashim Ali Abdulameer Alsherees

DOI: http://dx.doi.org/10.18535/jmscr/v4i4.58

Abstract

Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals, many environmental triggering factors are suggested to participate in its pathogenesis, Several studies were struggled to establish the association between some microbial infections and CD development, some of these studies were suggested an association between adenovirus infections and CD development, but this association still un confirmed yet, so that, this study aims to evaluate the role of previous adenovirus infections and its association with IFN-α in occurrence of celiac disease. Sample of 80 Iraqi celiac patients has been chosen from all suspected patients who attending to Al-Suder- Medical center during the period of April 2015 to November 2015, also 80 healthy individuals (control) were included in this study, all patients were undergo blood investigations for anti- adenovirus IgG ,AGA-IgA, AGA-IgG, tTG-IgA, tTG-IgG and IFN-α tests. Results showed no significant difference in levels of anti-adenovirus IgG in celiac patients compared to healthy group, p >0.05 and there is no significant correlation between IFN-α and anti-adenovirus IgG in celiac patients, P > 0.05. Alsono significant correlation between anti-adenovirus IgG and AGA-IgA,P > 0.05 and no significant correlation between anti-adenovirus IgG and AGA-IgG, P > 0.05, andno significant correlation between anti-adenovirus IgG and tTg-IgG, P > 0.05. In other hand, there is significant correlation between anti-adenovirusIgG and tTg-IgA, P < 0.01.

Key words: Celiac disease, adenovirus, IFN-α, AGA, tTG-IgA.

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Corresponding Author

Hashim Ali Abdulameer Alsherees

Assist. Lecture, Department of Microbiology

College of Medicine/University of Kufa