Title: Effect of Intravenous Administration of Ketorolac As Preventive Analgesia To Pupil In Eye Surgery With General Anesthesia
Authors: Andriamuri Primaputra Lubis, Hasanul Arifin, Erna Mutiara
DOI: http://dx.doi.org/10.18535/jmscr/v4i4.48
Background: NSAID (Non steroid anti inflammatory drug ) inhibit cyclooxygenase enzyme and also inhibition of proinflamation prostaglandin (PG). Ketorolac has recommended for a short time use on post operation, not longer than 2 days intravenous administration. So this drugs is good for acute analgesia. The research useful for looking an effect of ketorolac administration as a preventive analgesia concern to pupil in prevent myosis in eye’s surgery within general anesthesia. Methods: it was a quasi experimental study done in Sumatera Eye Centre Hospital, Medan, Indonesia during January to June 2012. Sampling was taken using total sampling method with 44 patients. Results: There is no significant difference in myosis for patient with ketorolac as preventive analgesia in eye surgery Keywords: ketorolac, preventive, analgesia, eye surgery, general anesthesia 1. Hausser MW, Valley RD, Bailey AG. Anesthesia for pediatric ophthalmology surgery. In: Smith, editor. Textbook of anesthesia for infants and children. Philadelphia: Mosby Elsevier; 2006, 770-88. 2. Aitkenhead AR, Rowbotham DJ, Smith G. Anesthesia for ophthalmic surgery. In: Aitkenhead AR, Rowbotham DJ, Smith G, editors. Textbook of anesthesia. 4th ed. Edinburgh: Churchill Livingstone; 2001, 594-605. 3. McGoldrick KE, Gayer SL. Anesthesia and the eye.,ln Barash DG, Cullen BF, Stuelting RK, editors. Textbook of clinical anesthesia. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2006, 974-96. 4. Heon E, Levin AV, Lam WC. Ophtahlamic surgery: surgical consideration. In: Bissonette B, Dalens BJ, editors. Textbook of anesthesia principles and practice. New York: McGraw Hill; 2002, 1259-76. 5. Morgan GE, Mikhail MS, Murray MJ. Anesthesia for ophthalmic surgery. In: Morgan GE, Mikhail MS, Murray MJ, editors. Textbook of clinical anesthesiology. 4th ed. New York: Lange Medical Book; 2006, 826-36. 6. Stephen J.Kim,etc.Topical Ketorolac in Vitreoretinal Surgery,a prospective,randomized,placebo-controlled,double-masked Trial.Arch Ophthalmol.2008;126(9):1203-8 7. Yusuf M Suleiman,Najwa F.K,Aksam J.A.Comparison of Ketorolac Tromethamine and Prednisolone Acetate in Preventing Surgically Induced Miosis during Cataract Surgery.Squ Med J.2010;10:57-63 8. Munish A,Avinash S.D,Surendra K.S,Dipak K.M.Topical Ocular Delivery of NSAIDs.The AAPS Journal.2008;10:no 2. 9. Robert Stewart,Robert G,Janet K,Allan R.Efficacy and safety profile of ketorolac 0,5% ophthalmic solution in the prevention of surgically induced miosis during cataract surgery.clinical Therapeutics.vol 21;4:723-32 10. Richard Atanis,etc.Effect of topical ketorolac tromethamine and topical nepafenac on maintaining pupillary dilation during phacoemulsification.Philippine Journal of Ophthalmology.2011;36(1):23-7. 11. Cousins M. Acute and postoperative pain In : Melzack R, Wall PD. Editors. Handbook of pain management a clinical companion to wall and melzack’s textbook of pain. London : churchill Livingstone ; 2003,p.13-30. 12. Provenzano DA, Grass JA. Is epidural Analgesia superior to iv PCA?. In: Fleisher LA, editors. Evidence-Based Practice of Anesthesiology Philadelphia; Sauders;2004, p.442-4. 13. Basuki G.Peran Ketorolak pada pengelolaan nyeri paska bedah.In: Buku kumpulan makalah KONAS Indonesian Pain Society.Makassar.2002.p 66-68 14. Stoelting RK. Prostaglandins. In : Stoelting RK, eds. Pharmacology and Phisiology in Anaesthetic Practice. Philadelphia : Lippincott, 1991: p. 384-91. 15. 28. Kelly DJ. Ahmad M. Sorin J. Brull MD. Preemptive analgesia II: recent advances and current trens. Can J Anest 2001;48(11): p.1091-1101 16. Dekens J. Lepointe F, Besserve P. Analgesia Post Operatoire en Chirurgie Osteoarticulaire par Le Ketoprofene en Perfusion. Cahaiers d’Anesthesiologie, Janvier-Fevrier, 1988; 36: p.25-7. 17. Guadalupe C,etc.Inhibition of Surgically induced miosis and prevention of postoperative macular edem with nepafenac.Clinical Ophtalmology,2009:p.219-26Abstract
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