Neonatal Screening Program, Study of Congenital Hypothyroidism Cases

Title: Neonatal Screening Program, Study of Congenital Hypothyroidism Cases

Authors: Dr Basil Metti Hanoudi, Najla I.Ayoub, Rasha S. Abdulraheem

DOI: http://dx.doi.org/10.18535/jmscr/v4i4.45

Abstract

Introduction: Congenital hypothyroidism is one of the most common preventable causes of mental retardation. The clinical manifestations are so subtle that many newborns are undiagnosed at birth.

Aim of study: Studying neonatal screening in Baghdad city and cases of hypothyroidism in screened infants, regarding; clinical presentation, treatment and follow up of cases.

Patients and methods: A retrospective descriptive study was done in Baghdad city for babies screened over the period 1^st of Nov 2015 to 31^st of Jan 2016. Data about screening program was collected over the period of 1^st April 2013 to 31^st October 2015 and 1^st May 2013 to 31^st October 2015 respectively.

Results: The total number of screened newborns was 441206 (249835 in Al-Rusafa and 191371 newborns in Al-Karkh) with average screening coverage of 59.9%. The overall proportion of occurrence of congenital hypothyroidism was 1:2141, phenylketonuria 1:6787, and galactosemia 1:21009. The study group included screened newborns patients from Al-Karkh hospitals (24 patients). The female : Male ratio patients in Al-Karkh was 1.6:1. There was a significant association of positive linear growth increment in symptomatic group of patients (P 0.044). A positive change in linear growth showed significantly younger aged patients (P 0.025) and higher admission TSH level than no change (P 0.001). There was a significantly higher level of admission TSH in delayed developmental milestone in the study group of patients (P 0.016).

Conclusion: *Efforts to bypass the drawbacks of work routines

*Enhance and encourage public education for notification of confirmed cases to attend tertiary centers

Key words: neonatal screening, hypothyroidism, development assessment, thyroxine, clinical features

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Corresponding Author

Dr Basil Metti Hanoudi

Al Mustaansiriya University, College of Medicine

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