Immunohistochemical Analysis & Correlation of EGFR and Ki-67 Expression Status with Clinicopathological Parameters in Head and Neck Squamous Cell Carcinomas: An Indian Perspective

Title: Immunohistochemical Analysis & Correlation of EGFR and Ki-67 Expression Status with Clinicopathological Parameters in Head and Neck Squamous Cell Carcinomas: An Indian Perspective

Authors: Dr Prerna Chadha, Dr Nikhilesh Kumar, Dr Rigvardhan, Dr Prashant Sengupta, Dr Richa Ranjan

DOI: http://dx.doi.org/10.18535/jmscr/v4i5.37

Abstract

Head and neck squamous cell carcinoma (HNSCC) is sixth most common neoplasm worldwide and despite the progress made in the diagnosis and treatment, the survivalof these patients has not improved significantly^[1]. Therefore a vigilant search for newer diagnostic and prognostic markers along with fresh molecular targets is required for the prevention & cure of HNSCCs and related tumors.

References

1. More Y, D’Cruz AK. Oral Cancer: Review of current management strategies. Natl Med J India. 2013 May-Jun; 26(3):152-8

2. Zimmermann M, Zouhair A, Azria D, Ozsahin M. The epidermal growth factor (EGFR) in head and neck cancer: its role and treatment implications. RadiatOncol. 2006;1:11-15.

3. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown.J Cell Physiol. Mar 2000; 182(3):311-22.

4. Barber BR, Biron VL, Klimowicz AC, Puttagunta L, Côté. Molecular predictors of locoregional and distant metastases in oropharyngeal squamous cell carcinoma. Journal of Otolaryngology- Head and Neck Surgery.2013;42:53.

5. Sarkis SA, Abdullah BH, Majeed BA, Nazar G. Biochemical markers EGFR , VEGF, PCNA, P53 and D2-40 in head and neck squamous cell cancers. Head Neck Oncol. 2010; 2: 13.

6. Kalyankrishna S, Grandis JR. Epidermal growth factor receptor biology in head and neck cancer. J ClinOncol. 2006 Jun 10; 24 (17):2666-72.

7. Smith BD, Smith GL, Carter D. Molecular marker expression in oral and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2001;127:780–785.

8. Smita SB, Radhika MB, Paremala K, Sudhakara M.Expression of Ki-67 in normal oral epithelium, leukoplakic oral epithelium and oral squamous cell carcinoma. J Oral MaxillofacPathol. 2014 May-Aug; 18(2): 169–176

9. Ashraf MJ, Maghbul M, Azarpira N and Khademi B. Expression of Ki-67 and P53 in primary squamous cell carcinoma of the larynx. Indian J PatholMicrobiol. 2010;53 (4):661-5.

10. Gröbe A, Eichhorn W, Fraederich M, Kluwe L, Vashist Y J. Immunohisto-chemical and FISH analysis of EGFRand its prognostic value in patients with oral squamous cell carcinoma . Oral Pathol Med.2014 Mar;43(3):205-10.

11. Lin YT, Chien CY, Lu CT, Lou SD, Lu H, Huang CC. Triple-positive pathologic findings in oral cavity cancer are related to a dismal prognosis. Laryngoscope. 2015 Sep;125(9):E300-5. doi: 10.1002/lary.25463. Epub 2015 Jul 7.

12. Yeh CF, Li WY, Yang MH, Chu PY. Neck observation is appropriate in T1-2, cN0 oral squamous cell carcinoma without perineural invasion or lympho vascularinvasion. Oral Oncol.2014Sep; 50 (9):85762.

Corresponding Author

Dr Prerna Chadha

Resident,Dept. Of Pathology, Command Hospital,

Central Command, Lucknow