Title: PCI Vs Thrombolytic Therapy in Acute Myocardial Infarction-A Review
Authors: Sanjay Madhavan, Dr Naufal Rizwan
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.78
Aim: The aim of this article is to provide a review on percutaneous coronary intervention vs thrombolytic therapy in acute myocardial infarction. Objective: To provide a comparison between percutaneous coronary intervention vs thrombolytic therapy in the treatment of acute myocardial infarction. Background: Myocardial infarction (MI) is the irreversible necrosis of heart muscle secondary to prolonged ischemia. Myocardial infarction is considered a part of a spectrum referred to as acute coronary syndrome (ACS). The Acute coronary syndrome consists of unstable angina, non–ST-segment elevation MI (NSTEMI), and ST-segment elevation MI (STEMI). As a general rule, initial therapy for acute myocardial infarction is directed towards restoration of perfusion as soon as possible to salvage as much of the jeopardized myocardium as possible. This may be accomplished through medical, drugs or mechanical means, such as Percutaneous coronary intervention or Coronary artery bypass grafting. Thrombolytic therapy is the use of drugs to break up or dissolve blood clots, which are the main cause of both heart attacks and stroke. They include drugs like alteplase, reteplase, streptokinase, tenecteplase etc. Percutaneous coronary intervention (PCI), commonly known as coronary angioplasty, is a procedure where in stents are kept in the stenotic (narrowed) coronary arteries, thus improving the blood flow to the heart and relieving it from compromised blood supply. Reason: To provide a comprehensive review about indications, advantages and disadvantages of percutaneous coronary intervention and thrombolytic therapy in acute myocardial infarction and find the better off the two 1. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: Part I: evolving concepts. J Am Coll Cardiol. 2005;46:937-954. 2. 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