Title: Relationship of Thyroid Hormone Status and Serum Fluoride Level among the Tribal Peoples – A Cross-sectional Descriptive Study
Authors: Suman Chatterjee*, Sumanta Banerjee, Tanmay Ray, Sailen Kumar Bhattacharyya
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.76
Now-a-days, fluorosis is one of the important public health problems in many regions of Indian subcontinent. The present cross-sectional observational study had been undertaken at Simlapal block, one of the fluoride endemic zones of Bankura district, West Bengal, India to evaluate the relationship between thyroid hormone status and serum fluoride level among the tribal population. This study was carried on 67 fluorosis cases. Serum samples were collected from the cases and serum fluoride level was estimated by Ion-Meter and serum Thyroid stimulating hormone (TSH), free Triiodothyronine (fT3) and free Thyroxine (fT4) levels were measured by ELISA method. It was observed that there was a female preponderance in hypothyroidism compared to the male subjects who were suffering from fluorosis. This study also exposed that out of 67 cases 12 (ie, 17.91%) were suffering from hypothyroidism. Keywords- Fluorosis, Serum fluoride, TSH, fT3, fT4 1. Passmore R et al. Hand book of Human Nutritional Requirements. Monger Ser World Health Organ.1974; 61: 1-66. 2. Park K. Park’s text book of Preventive and Social Medicine. 21st Ed. Jabalpur, India: M/s Banarasisdas Bhanot Publishers. 2011: 577. 3. Guidelines for drinking water quality. Geneva: WHO; 2004.World Health Organization. 4. Saravanan S et al. Prevalence of dental fluorosis among the primary school children in rural area of Chidambaram Taluk, Cuddalore District, Tamil Nadu. India, Indian J Commun Med.2008; 33: 146-50. 5. Kotecha PV, Patel SV, Bhalani KD, Shah D, Shah VS, Mehta KG. Prevalence of dental fluorosis & dental carries in association with high levels of drinking water fluoride content in a district of Gujrat, Indian J Med Res. 2012; 135(6): 873-877. 6. National Programme For Prevention And Control of Fluorosis Bankura – Inter departmental Sensitization on Fluorosis. CMOH Office, Bankura. 2015. 7. Kasper, Fauci Hauser Longo, Jameson J L, Loscalzo J eds. Harrison’s Principles of Internal Medicine. 19th ed. USA: McGraw-Hill Education; 2015. 8. Murray RK. Harper’s Illustrated Biochemistry. 29th ed. McGrawHill Lange. 2012. 9. Shasi A ,et al 2013. Clinical and Biochemical Profile of Deiodinase Enzymes and Thyroid Function Hormones in Patients of Fluorosis . Australian Journal of Basic and Applied Sciences. 2013; 7(4): 100-107. 10. Susheela A.K. Fluorosis management programme in India. Current Science. 1999; 77(10): 1250–1255. 11. . 12. Susheela AK, Bhatnagar M, Vig K, Mondal NK. Excess fluoride ingestion and thyroid hormone derangements in children living in Delhi, India. Fluoride. 13. Census of India 2011, Office of the Registrar General and Census Commissioner. Ministry of Home Affairs, Govt. of India. Available from: http:// www.censusindia.gov.in. 14. N. Singh et al. A comparative study of fluoride ingestion levels, Serum thyroid hormones and TSH level derangements, dental fluorosis status amongst school children from endemic and non-endemic fluorosis areas. Springerplus. 2014. 15. Gopalkrishnan AU et al. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian Journal of Endocrinology and Metabolism. 2013; 17(4): 647-652. 16. Mahato RV, Nepal AK, Gelal B, Poudel B, Yadav BK, Lamsal M. Spectrum of thyroid dysfunction in patients visiting Kantipur Hospital, Kathmandu, Nepal. Mymensingh Med J. 2013; 22: 1649. 17. S. Singla et al. Thyroid peroxidase activity as toxicity target for fluoride in patients with thyroid dysfunction. Current Research in microbiology and Biotechnology. 2013; 2: 53–57.Abstract
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