Title: Serum Iron and Total Iron Binding Capacity in Preeclampsia
Authors: A. P. Moholkar, K. N. Pujari, M. P. Bankar, S. P. Jadkar
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.73
Preeclampsia (PE) is a pregnancy-specific condition that increases maternal and infant mortality and morbidity. Exact etiology of preeclampsia is still not known but certain hypothesis suggest it may be associated with an increased vascular resistance of uterine artery and decrease in perfusion of placenta. It has been suggested that lipid peroxidation plays an important role in the etiology of preeclampsia. Iron and hematin proteins play important roles as catalysts of lipid peroxidation in tissues. The aim of study was to estimate and compare serum iron and total iron binding capacity in preeclamptic women and normal pregnant women. Study was conducted in Government Medical Hospital Miraj with 120 subjects. The studied population consisted: group I (40 normal pregnant women) and group II (80 pregnant women with preeclampsia). Serum iron and total iron binding capacity values were measured by ferrozine method. We found significantly high serum iron and significantly low total iron binding capacity in preeclamptic women as compare to normal pregnant women (p<0.001). So elevated serum iron and decreased total iron binding capacity may play an important role in the pathogenesis of preeclampsia. Key words: Iron, Preeclampsia, Total iron binding capacity 1. Uzma Shamsi, Sarah Saleem, Noureen Nishter. Epidemiology and risk factors of preeclampsia; an overview of observational studies. Al Ameen J Med Sc i 2013; 6(4):292-300. 2. Jennifer Uzan, Marie Carbonnel, Olivier Piconne, Roland Asmar, Jean-Marc Ayoubi. Pre-eclampsia: pathophysiology, diagnosis, and management. Vascular Health and Risk Management 2011:7 467–474. 3. Rana M Hameed, Wasan Gh. Aboud. Total iron binding capacity (TIBC), free iron, ceruloplasmin, transferrin and ferritin concentration in pregnant women with preeclampsia. Magazin of Al-Kufa University for Biology 2013;5(2):1-7. 4. A P Moholkar, M P Bankar, K N Pujari, S P Jadkar. Serum calcium and magnesium levels in preeclampsia. Serum calcium and magnesium levels in preeclampsia. International Journal of Pharmacy and Biological Sciences Jul-Sept 2014; 4(3):42-45. 5. Dr. Tasneem Zafar, Dr Zafar Iqbal. Iron status in preeclampsia. Professional Medical journal Mar 2008; 15(1):74-80. 6. Tietz NW “Text book of clinical chemistry 2nd edition “Tietz NW (Ed) WB Saunders Company Philadelphia 1994; 2059 7. Cao G, Prior R L. Clinical Chemistry Anthocyanins and iron metabolism in human serum 1999b; 574-76. 8. National committee for Clinical Laboratory Standards User Evaluation of precision performance of clinical chemistry devices. NCCLS. 1984 NCCLS publication EPS-T. 9. Shakuntala Masti, Dattatreya K. Study of serum iron and total iron binding capacity in preeclampsia. International journal of pharmacy and Biological Sciences Jan - Mar 2014; 4(1):69-74. 10. Rahab Mohamed Osman, Gad Allah Modawe, Abd Elkarim A. Abdrabo. Assessment of iron status in pregnant ladies with preeclampsia. International journal of Research in Pharmacy and Biosciences Feb 2015; 2(2): 8-11. 11. Sabitha Kandi, Sudhakar T, C Venugopal, Rajkumar, Md Rafi, K V Ramana. Preeclampsia and iron status: a review. American journal of Medical and Biological Research 2014; 2(6):121-123. 12. Hulya A, Seyithan T, Konca A, Ebubekir B, Nuri B, Yakup K. Antioxidant potential and transferrin, ceruloplasmin and lipid peroxidation levels in women with preeclampsia. Journal of Investigative Medicine 2003; 51(5): 284-287. 13. K N Pujari, S P Jadkar. Superoxide dismutase levels in leukemias. International journal of Basic Medical Sciences July 2011; 2(2):96-100. 14. D M Vasudevan, Sreekumari S, Kannan Vaidyanathan. Free radicals and antioxidants: in Textbook of Biochemistry for medical students 7th edition, published by Jaypee brothers 2013, p 433-438.Abstract
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