Title: PET/MRI: Current Prospects and Challenges
Authors: Ritu Kela (PhD), Nida Khan (M.Tech), Anand Priyadarshi (B.Sc), Pinky Payal (B.Sc)
DOI: http://dx.doi.org/10.18535/jmscr/v4i6.08
PET/MRI is a hybrid imaging technology, increasingly being used in research applications as well as in clinical practice. The combined PET/MRI system is the latest in fusion imaging. The device provides specific molecular information related to cell surface receptors and enzymes and gene expression with high sensitivity, delivered by PET. Simultaneously, it also captures important anatomical data, superior soft tissue contrast, spatial resolution and information about perfusion and permeability, shown by MRI. Therefore it proves to be a highly sensitive and evaluator clinical investigation technique. PET/MRI is an expensive technology and its availability is extremely limited across the world. It still need further technical and clinical upgradations for better prospects and prove beneficiary towards the patients. However, initial experience with this new imaging system is very promising for oncology, cardiac imaging and neuro imaging. Not only pediatric and young oncologic patients but pregnant women would also be benefitted from PET/MRI. There are potential competitive advantages of PET/MRI over PET/CT. But, it is struggling to show its superiority over its arch-rival PET/CT in many cases. The aim of this paper is to review the current status of PET/MRI in clinical applications and its challenges. Key words - PET-MRI , hybrid , oncology , staging , Pediatric 1. Dr. Frank Prato. St. Joseph’s health care, Ontario, Canada. 2. Pichler BJ, Wehrl HF, Kolb A, Judenhofer MS. PET/MRI: The next generation of multimodality imaging ? Semin Nucl Med. 2008;38(3) : 199-208. 3. Schlemmer HP, Pichler BJ, Schmand M, et al. Simultaneous MRI/PET Imaging of the human brain : feasibility study. Radiology. 2008; 248(3) : 1028-35. 4. Karin Anna Herrmann, Andres A. Kohan Maria Chiara Gaeta, Christian Rubbert, Jose Luis Vercher – Conejero, Raj mohan Paspulati , Kalemis Antonis, Bahar Munsoori,, Peter. F. Faulhaber, Nobert Avril, Pablo Riera Ros. PET/MRI : Application in Clinical Imaging. Current Radiology Reports. Volume 1, issue 3, PP 161-176 September 2013. 5. Stony Brook School of Medicine Newyork, USA. 6. Hossein Jadvar, Partick M. Colleti. Competitive advantage of PET/MRI. European journal of Radiology. 2014 Jan; 83(1) : 84-94 7. Facilities – Icahn School of medicine, mount Sinai (USA) 8. University Hospital of Geneva (HUG) Switzerland. 9. Dr. Gary Cowin, Centre for advanced imaging, University of Queensland, Brisbane, Australia. 10. Siemens: Ref Number: CC/PR/3/H IM 02 2013. 11. House of Diagnostic (HOD), New Delhi, India. 12. Christopher M Rank christoph Tremmel, Nora Hunemohr Armin M Nagel, Oliver Jakel, steffen Greilich. MRI based treatment Plane simulation and adaptation for ion radiotherapy using a classification- based approach: Radiation oncology. 2013; 8:51 13. Sasan Partovi, Andres Kohan, Christian Rubbert , Jose Luis Vercher - Conejero chaiara Gaeta, Roger Yuh, Lisa Zipp, Karin A Hermann, Mark R Robbin, Zhenghong Lee, Raymond F Muzic Jr, Peter Faulhaber and Pablo R Ros. Clinical oncology applications of PET/MRI : A New horizon : American Journal of nuclear medicine and molecular imaging. 2014; 4(2) : 202-212. 14. Pearce Ms, Salolti JA, Little MP, Mc Hugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de Gonzalez A. Radiation exposure from CT Scans in childhood and brain tumours : A retrospective cohort study. Lancet. 2012; 380 : 499 – 505. 15. Isabel Rauscher, Ambros J. Beer, Christoph schaeffeter, Michael Souvatzoglou, Moritz Cronlein, Chlodwig Kirchhoff, Gunther Sandmann, Sebastian Furst, Robert Kilger, Michael Herz, Sybille Ziegler Markus Schwaiger, Matthias Eiber; Evaluation of 18F- Fluoride PET/MR and PRT/CT in Patients with unclear foot pain. Journal of Nuclear Medicine, Feb 2015: Doi : 10.2967/ Jnumed . 114. 150532. 16. Shubham Sogani. House of diagnostic, Indraprastha Apollo Hospital, Delhi, India 17. Cancer the big picture. Business standard , 18 Oct 2014. 18. Satish K. Bhargava, Textbook of Radiology for residents and technicians, 5th edition, PP 629. 19. Siemens health care, Germany 20. Radiological Society of North America (RSNA). 101st Scientific assembely and annual meeting. 29 Nov – 4 Dec 2015 Chicago (USA) 21. Dr. Jean Theberge : Lawson health research institute, Canada 22. Claudio spick, Ken Herrmann, Johannes Czernin. 18F-FDG PET/CT and PET/MRI perform equally well in cancer patients: Evidence from studies in more than 2300 patients. Journal of Nuclear Medicine, March 2016, vol.57:3, PP.420-430.Abstract
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