Title: Primary Squamous Cell Carcinoma of the Breast – A Rare Case Report
Authors: Prof. Dr C. V Kulkarni, Dr Shweta Joshi, Dr Priyanka Solanki, Dr Jyoti Chauhan
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.43
Squamous cell carcinoma of the breast is an uncommon breast neoplasm. A forty five year old woman, was referred to Maharaja Yashwantrao Hospital, Indore following a diagnosis of carcinoma breast. She noticed a painless swelling in the right upper quadrant four weeks earlier and simultaneously developed a mass in the axillary region. A Fungating growth on the skin was identified. Physical examination revealed fungating growth in the skin, with no mass in the axilla. The occurrence of pure squamous cell carcinoma in younger age group is a rarity. Squamous cell carcinoma of breast is one such mystery, which is encountered very rarely. Its clinical behavior should not be correlated with the standard infiltrating duct carcinoma of breast. It follows an atypical presentation in terms of tumor size, lymph node and systemic spread. Squamous cell carcinoma of the breast is a rare and aggressive disease, and it has significantly worse prognosis than other nonsquamous cell tumours of the breast. Clinicians should be aware of aggressive nature of the tumour when counseling patients. KEY WORDS: Carcinoma breast, squamous cell carcinoma (SqCC). 1. Stevenson JT, Graham DJ, Khiyami A, Mansour EG: Squamous cell carcinoma of the breast: A clinical approach. Ann Surg Oncol 1996, 3:367-374. 2. Gupta G, Malani AK, Weigand RT, Rangenini G: Pure primary squamous cell carcinoma of the breast: A rare presentation and clinicopathologic com-parison with usual ductal carcinoma of the breast. Pathol Res Pract 2006, 6:465-469 3. Rosen PR: Squamous Carcinoma. In Rosen’s Breast Pathology. 2nd edition. Edited by Lippincott Williams & Wilkins. Philadelphia; 1997:455-461. 4. Moisidis E, Ahmed S, Carmalt H, Gillett D: Primary squamous cell carcinoma of the breast. ANZ J Sur 2002, 72:65-67. 5. Rostock RA, Bauer TW, Eggleston JC: Primary squamous carcinoma of the breast: A review. Breast 1984, 10:27-31. 6. Behranwala KA, Nasiri N, Abdullah N, Trott PA, Gui GP: Squamous cell carcinoma of the breast: Clinico-pathologic implications and outcome. Eur J Sur Oncolo 2003, 29:386-389. 7. Howlader N NA, Krapcho M, Garshell J SEER Cancer Statistics Review, 1975–2012. Bethesda, MD National Cancer Institute Available at: http://seerca-ncergov/csr/1975_2012/, based on November 2014 SEER data submission, posted to the SEER web site, April 2015 8. Siegelmann-Danieli N, Murphy TJ, Meschter SC, Stein ME, Prichard J. Primary squamous cell carcinoma of the breast. Clinical of breast cancer 2005;6(3):270–2. 9. Karamouzis MV, Fida A, Apostolikas N, Rigatos G. A case of Her-2 positive squamous cell breast carcinoma: an unusual presentation of an unusual clinical entity. EJSO 2006;32:1250–1. 10. Breuer A, Kandel M, Fisseler-Eckhoff A, Sutter C, Schwaab E, Lück H, et al. BRCA- 1 germline mutation in a women with metaplastic squamous cell breast cancer. Onkologie 2007;30:316–8.Abstract
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