Title: Study on Thyroid Hormone, FSH, LH and Prolactin Levels in Patients with Primary Infertility: A Hospital Based study
Authors: Dr M. K Gupta, Dr Asim Singh
DOI: http://dx.doi.org/10.18535/jmscr/v4i7.41
The thyroid dysfunction, which is quite prevalent in the population, affects many organs including male and female gonads, thus interfering with the human reproductive physiology. Prolactin has suppressive effect on the pituitary –ovarian axis and may result in amenorrhea or oligomenorrhea due to anovulatory cycles. Hyperprolactinemia is a common problem in reproductive dysfunction, affecting about one third of infertile women. A positive correlation was found between TSH and prolactin i.e elevated TSH levels were associated with elevated prolactin levels in infertile patients. So TSH screening of all females of early reproductive age group should be done so as to detect subclinical thyroid problem and to prevent infertility risk. Keywords: Thyroid profile, FSH, LH and Prolactin. 1. Goswami B., Patel S., Chaterjee M., Koner B.C., Saxena A. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J ReprodInfertil. 2009;10(3):207-12. 2. Comprehensive Thyroid Assessment. Gen-eva Diagnostics. Retrieved on 2007-05-21. 3. Longcope C. The male and female reproductive systems in hypothyroidism. In Werner and Ingbars. The Thyroid a Fundamental Clinical Text, eds L braverman & GB Lipincott, Philadelphia – New Yark 1996; p.849-852. 4. Van Wyck JJ, Grumbach MM. Syndrome of precocious menstruation and galactorrhea in juvenile hypothyroidism. An example of hormonal overlap pituitary feedback. JPediatr 1960; 57: 416-435. 5. Koutras DA. Disturbances of menstruation in thyroid disease. In Adolescent Gynecology and Endocrinology eds G. Kreatsas, G. Mastorakos& G. Chrousos. Am NY AcadSci 1997; 816: 280-284. 6. Reilly WA. Thyrotoxicosis. Am J Dis Child 1940; 60: 79-87 7. . Poppe K, Glincer D, Van Steirtigham A, Tournay H, Devroey P, Schietaecattle J et al.; Thyroid dysfunction and automimmu-nity in infertile women. Thyroid, 2002; 12(11): 997-1001. 8. Murray RK, Granner DK, Mayer PA, Rodwill VW; Pituitary and hypothalmic hormones Quoted in Harpes’s Bio-chemistry, 25th Edition, 2000: 550-559. 9. Hemedy ZS, Siler-Khodr TM, Najjar S; Precocious puberty in juvenile hypothyroidism. J Pediatr., 1978; 92(1): 55-59. 10. Maruo T, Hiramatsu et al: Increase in the expression of thyroid hormone receptors in porcine granulose cells early in follicular maturation ActaEndocrinal 1992;127:1562 -60. 11. Armada Dias L, et al Is the infertility in hypothyroidism mainly due to ovarian or pituitary functional changes. Braz J Med Biol Res 2001; 39 1209 15. 12. Moretti C, et al : Dynamic evolution of ovarian reserve and abnormal androgen excess in women J Endocrinal Invest 2003:26 (suppl,) 111-123. 13. Haraguchi K,et al: Thyrotropin-dependent desensitization of Chinese hamaster ovary cells that express the recombinant human thyroreceptor.J Endocrinol 1993;139:425. 29. 14. Maruo T, et al :The role of thyroid hormone as a biological amplifier of the actions of FSH in the functional differ-entiation of cultured porcine granulose cells Endocrinology 1987;121:1233-1241. 15. Cecconi S, et al: Thyroid hormone effects on mouse oocyte maturation and granulose cell aromatase4 activity. Endocrinology. 1999; 140 ;1783 – 1788. 16. Zahringer S,et al ;The influence of hyperthyroidism on the hypothalamic-pituitary-gonadal axis. 17. Avasthi K, Kaur J, Gupta S, Narang PA; Hyperprolactenemia and its correlation with hypothyroidism in infertile women. J Obstet Gynecol India, 2006; 56(1): 68-71.Abstract
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