Prevalence and Risk Factors of Prolonged QTc Interval among Egyptian Type 2 Diabetes Patients

Title: Prevalence and Risk Factors of Prolonged QTc Interval among Egyptian Type 2 Diabetes Patients

Authors: Mohamed M. Aboelnaga, Maha M elshafe, Eman Elsayed

DOI: http://dx.doi.org/10.18535/jmscr/v4i7.24

Abstract

Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Egyptian patients with type 2 diabetes.

Patients and methods: We enrolled in this cross-sectional study from June 2011 to December 2015, a total of 220 patients (108 male & 112 female) with mean age 50.42± 7.453years diagnosed with type 2 DM.

Results: In this study, we found (33.6%) 74 T2 DM patients with QTc>440 ms had statistically significant longer diabetes duration and, diastolic BP, Total cholesterol. LDL-C and UACR with 146 type 2 DM patients with ≤ 440QTc ms (P value ≤ 0.05). Also statistically significant higher incidence of insulin therapy, retinopathy and nephropathy has been founded in 74 T2 DM patients with QTc>440 Ms.

By Pearson correlation, we found QTc interval significantly correlated with diabetes duration, Diastolic BP, TC , LDL-C and UACR., also by using multiple regression analysis we found LDL-c, diabetic duration and UACR were statistically significant predictors of QTc interval.

In logistic regression analysis for identification of risk factors for QTC interval prolongation, only LDL-c and UACR were statistically significant (P value<0.05) predictors of QTc interval.

Conclusion: Prolonged QTc prevalence among type 2 diabetic Egyptian patients was 33.6%. Although QTc prolongation was associated with longer diabetes duration, diastolic BP, total cholesterol, LDL-C, albumin urinary excretion, insulin therapy and retinopathy, only statistically significant predictors of QTc interval main risk factor for QTc prolongation were LDL-c and UACR.

Keyword: QTc; Bazett’s formula; Type 2 DM; Egyptian

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Corresponding Author

Mohamed M. Aboelnaga

Lecturer of Endocrinology, Faculty of Medicine

Mansoura University, Mansoura, Egypt

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile No. : +201009444705