Diabetic Nephropathy: Ultrasound, Color Doppler and Biochemical Correlation- A 2 Year Study

Title: Diabetic Nephropathy: Ultrasound, Color Doppler and Biochemical Correlation- A 2 Year Study

Authors: Manish Shaw, S.Bhagat, B.B.Panda, S. Nisa, B.Das, Amulya Panda

DOI: http://dx.doi.org/10.18535/jmscr/v4i8.58

Abstract

Aims & Objectives- To evaluate the biochemical parameters, sonomorphological and Doppler ultrasound findings in assessment of diabetic nephropathy and correlation among them.

Materials & methods-60 patients having type II diabetes mellitus who were referred to our department from December 2013 to September 2015 for either routine abdominal ultrasound or renal Doppler are randomly selected, categorised (4 subgroups) and studied using Philips HD 7 USG machine. Both kidneys were studied for dimensions, parenchyma thickness, echogenicity and resistive indices from interlobar arteries and biochemical tests were analysed by collecting the investigation reports. Correlations were studied between sonomorphological, Doppler USG and biochemical parameters. Statistical significance was ascertained using Microsoft Excel v10 (with data analysis tool kit) & Epi-Info v7.

Results- All patients in preclinical and incipient subgroup; more than half of the patients with renal failure were found to have normal renal parenchymal echogenicity. Around one third and 18.2% of patients had grade I and grade II cortical echogenicity changes in renal failure subgroup respectively. Most of the patients in preclinical group had normal RI value while patient belonging to other 3 subgroups had raised RI value (>0.7) with highest values in Renal failure subgroup.

Conclusions- Renal sonomorphological changes were noted in few patients and only in advanced stages of diabetic nephropathy but Resistive indices values were increased in most of the patients belonging to subgroups 2,3 and 4 and even in patients having normal sonomorphological features. Resistive indices values showed positive correlation with serum creatinine and blood urea nitrogen values suggesting complementary role of Doppler ultrasound in Diabetic nephropathy.

Keywords: Diabetic Nephropathy, Renal Doppler, Resistive Index.

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Corresponding Author

Manish Shaw

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