Title: Cytogenetic Study in Females with Secondary Infertility
Authors: Dr Rakhi M. More, Dr Milind P. More, Dr Shabana Borate, Dr S.D. Gangane
DOI: http://dx.doi.org/10.18535/jmscr/v4i8.24
Infertility affects approximately 10%-15% of couples in reproductive age. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in females suffering from secondary infertility [1]. We studied 67 females with history of secondary infertility to find out the proportion of cytogenetic causes in them. We observed chromosomal abnormalities in 2.98% females, of which showed structural abnormalities. Keywords:- Secondary infertility, Chromosomal abnormality, Female infertility, Karyotyping 1. Mohammad T. Akbari, F. Behjati,1 G. R. Pourmand,1 F. Akbari Asbagh,2 and M. AtaeiKachoui Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review. Indian J Hum Genet. 2012 May-Aug; 18(2): 198–203. 2. Nahla A. Nazmy Cytogenetic Studies of Couples with ReproductiveFailure in Alexandria, Egypt. J Egypt Public Health Assoc Vol. 83 No. 3 & 4, 2008 3. Greenhall E, Vessay M. The prevalence of subfertility: our view of the current confusion and a report of two new studies. Fertil Steril 1990; 54, 978-983. 4. Shah K, Sivapalan G, Gibbons N, Tempest H, Griffin DK. The genetic basis of infertility. Hum Reprod 2003; 126: 12–25. 5. World Health Organization (WHO). Current practices and controversies in assisted reproduction. Report of a meeting on “Medical, Ethical and Social aspects of assisted reproduction” Geneva, World Health Organization 2002. 6. Dutta S, Guha RA. Clinico- anatomical study on the etiological factors pertaining to primary infertility in females using some common investigative procedures. J Anat Soc India 2007; 56: 114–147. 7. Lungeanu A, Stana A, Arghir A, Bari M, Budisteanu M. Cytogenetic abnormalities and reproductive failures. Medical Journal of Clinical Medicine. 2007;2(2):11-20. 8. Badovinac AR, Buretic-Tomljanovic A, Starcevic N, Kapovic M, Vlastelic I, Randic L. Chromosome studies in patients with defective reproductive success. Am J Reprod Immunol. 2000; 44:279-83. 9. Wilcox AJ, Weinberg CR, O Connor JF. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189-94. 10. Wilcox AJ, Baird DD, Weinberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med. 1999; 340:1796- 9 11. Ohno M, Maeda T, Matsunobu A. A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi. Obstet Gyncol. 1991; 77:394-8. 12. Hogge WA, Bymes AL, Lanasa MC, Surti U. The clinical use of karyotyping spontaneous abortions. Am J Obstet Gynecol. 2003;189: 397- 400. 13. Neri G, Serra A, Campana M, Tedeschi B. Reproductive risks for translocations: cytogenetic study and analysis of pregnancy outcome in 58 families. Am J Med Genet. 1983;16:535-61. 14. Sherrod RA. Understanding the emotional aspects of infertility: Implications for nursing practice. J. Psychosocial Nurs. Mental Health Services. 2004;42:40–7. [PubMed] 15. Cates W, Farley TM, Rowe PJ. Worldwide patterns of infertility: Is Africa different? Lancet. 1985;2:596–8. [PubMed] 16. Warburton D, Fraser FC (1964). Spontaneous abortion risks in man: Data from reproductive histories collected in a medical genetic unit. Am J Hum Genet 16.1 17. Puri RK, Khanna KK, Bhargava I, BalakrishnanS (1977). Role of consanguinity in chromosomal disorders. Indian J Med Res 65: 859-864. 18. Novak’s Gynaecology, 13th edition pg 973-1107 19. Cech JA (1960). Pregnancy loss and toxoplasma, Progr Obstet Gynecol 11:41. 20. Kimbell CA (1971). Association of toxoplasma with recurrent spontaneous abortion, J Obstet Gynecol 3: 111-21. 21. Robb J, Benirshke K, Barmeyer R (1986). Intrauterine latent herpes simplex virus infection: spontaneous abortion Hum Pathol 17: 1196-206. 22. Alshuler G, (1974). Immunologic competence of the immature human fetus : morphologic evidence from intrauterine cytomegalovirus infection. Obstet Gynecol 43: 811-816. 23. Rao A. Kamini. ‘The Infertility Manual’ 2nd edition pg 42-53,126-131 and 528-535. 24. Abramsson L, Beckman G, Duchek M, Nordenson L. Chromosomal aberrations and male infertility. J. Urol. 1982;128:52–3. [PubMed] 25. Poland BJ, Miller JR, Jones DC, Trimble BK (1997) Reproductive counselling in patients who have had a spontaneous abortion. Am J Obstet Gynecol 127: 685. 26. Duzcan F, Atmaca M, Cetin G and Bagci H (2003). Cytogenetic studies in patients with reproductive failure. Acta Obstet Gynecol Scand , 82: 53 – 56. 27. Shaffer LG, Spikes AS, Mocha M, Dunn R (1996). Identification of subtle chromosomal translocation in a family with recurrent miscarriages and a child with multiple congenital anomalies. A case report. Kleberg Cytogenetics Laboratory, Houston, Texas 77030, USA.Abstract
References