Title: Clinicopathological Profile of Endometrial Carcinoma: A Regional Cancer Centre Experience

Authors: Samantaray Sagarika, Besra Kusum, Nayak Bhagyalaxmi, Pattanayak Lucy, Panda Niharika

 DOI:  http://dx.doi.org/10.18535/jmscr/v4i8.22

Abstract

The incidence of endometrial carcinoma is rising worldwide and more so in developing countries. One hundred and twenty four (124 cases) were analyzed in A.H. Regional Cancer Centre, Cuttack to find out different histopathological types, assess the parameters from surgicopathological specimens for staging according to 2009-FIGO criteria and to find out the relationship of tumor grading and lymph node metastasis. Majority of the cases were in stage I, 73% stage IA and 64% stage IB. Preoperative tumor grades were upgraded in 8 cases (8/104, 7.6%).Classical endometriod carcinoma was seen in 104 cases(83.8%) and non endometroid carcinoma in 20 cases(16.1%). Lymph node metastasis was observed in 12 cases mostly  grade 3 and nonendometrioid types 8 cases and only 4 cases of grade 2 carcinomas showed node metastasis.

Keywords: Endometrial carcinoma, tumor grade, FIGO staging, node metastasis.

References

 

1.      Endometrial Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up, Annals of Oncology 21(supplement 5)V 41-45,2010

2.      A retrospective clinicopathological study of 131 cases with endometrial cancers. Is it possible to define the role of retroperitoneal lymphadenectomy in low resource settings? Rathod PS,Peddihalli PV,Krishnappa S,Devi UK, Bafna UD. Indian Journal of Cancer , March 2014,volume 51,1:54-56

3.      Surgical pathological spread patterns of endometrial cancer. Creasman WT, Morrow CP,Bundy BN,Homesley HD,Graham JE,Heller PB. A Gynecologic Oncology Group Study. Cancer 1987;60:2035-41

4.      Clinicopathologic study of uterine endometrial carcinoma in young women aged 40 years and younger. Ota T, Yoshida M,Kimura M,Kinoshita K. Int J Gynecol Cancer.2005 Jul-Aug;15 (4):657-62

5.      FIGO committee on Gynecologic Oncology. Int J Gynecol Obstet 2009;105:103-104

6.      Surgical staging in endometrial cancer: Clinical pathologic findings of a prospective study.Boronow RC, Morrow CP, Creasman WT, Disara PJ, Silverberg SG, Miller A,et al.Obstet Gynecol 1984; 63: 825-32

7.      Adenocarcinoma of endometrium: Survival comparisions of patients with and without pelvic lymph node sampling. Kilgore LC, Partridge EE, Alvarez RD, Austin MJ, Shingleton HM, Noojin Fl, et al. Gynecol Oncol 1995;56:29-33

8.      Retrospective analysis of selective lymphadenectomy in apparent early stage endometrial cancer. Cragun JM, Havrilesky LJ, Calingaert B,Synam I, Secord AA, Soper JT, et al.J Clin Oncol 2005; 23: 3668-75

9.      The impact of complete surgical staging on adjuvant treatment decisions in endometrial cancer. Goude C,Berhard S,Cloven NG,Morris P.Gynecol Oncol 2004;93: 536-9

10.  Frozen  section analyses as predictor of lymphatic spread in patients with early uterine cancer.  J Am Coll Surg 2004; 199: 388-93.

Corresponding Author

Dr Lucy Pattanayak

490/B, Santa Sahi, Canal Road, Bajrakabati, Cuttack, Orissa

Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Tel # 91-9937028362