Title: Idiopathic Pulmonary Hypertension and Congenital Hypothyroidism: A Rare Case Report
Authors: Prof. Dr M.Senthilvelan, Dr S.Senthilkumar, Dr H.Resveen, Dr P.Suganya, Dr Jayaram Kosalram, Dr D.Kanagaraj, Dr G.Sivachandran, Dr G.Arulvenkatesh
DOI: http://dx.doi.org/10.18535/jmscr/v4i9.25
Idiopathic pulmonary artery hypertension (IPAH) is a rare, progressive, debilitating and fatal disease of unknown etiology. Congenital hypothyroidism is a relatively common condition, and longstanding thyroid dysfunction has been reported as a cause for IPAH. We report a case of 20 year old female patient presented with features suggestive of congenital hypothyroidism, she was found to have severe primary pulmonary hypertension and was started on treatment. The possible mechanism of pulmonary hypertension in this patient is discussed in this case report. 1. Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med. 2004;351 (16): 1655-65. 2. Rubin LJ; American College of Chest Physicians. Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guide-lines. Chest. 2004;126(1 Suppl):4S-6S. 3. Sociedade Brasileira de Pneumologia e Tisiologia. Diretrizes Brasileiras para Manejo da Hipertensão Pulmonar. J Bras Pneumol. 2005;31(Suppl 2):S1-S31. 4. Runo JR, Loyd JE. Primary pulmonary hypertension. Lancet. 2003;361(9368): 1533-44. 5. Ingbar DH. The pulmonary system in thyrotoxicosis. In: Werner SC, Ingbar SH, Braverman LE, Utiger RD. Werner and Ingbar’s The Thyroid: A fundamental and clinical text. Philadelphia: Lippincott Williams and Wilkins; 2000. p. 340-350. 6. Nakchbandi IA, Wirth JA, Inzucchi SE. Pulmonary hypertension caused by Graves’ thyrotoxicosis: normal pulmonary hemodynamics restored by (131)I treatment. Chest. 1999;116(5):1483-5.Abstract
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