Evaluation of Serum Level of Apelin in Patients with Atopic Dermatitis

Title: Evaluation of Serum Level of Apelin in Patients with Atopic Dermatitis

Authors: Prof. Dr Magdi Abd Aziz Ragab, Prof. Dr Magdi Mamdoh El Bardini, Prof. Dr Tarek Mahmoud Hussein, Sabrin Ebrahim Ahmed Ebrahim

DOI: http://dx.doi.org/10.18535/jmscr/v4i9.19

Abstract

Background: Atopic eczema (AE), also known as atopic dermatitis, is a chronic inﬂammatory skin disorder, characterized by cutaneous dryness, intense itching, scratching, skin damage, and secondary infections. Its cause remains unknown, although it is probably a combination of genetic, environmental, and immunologic factors. The prevalence of AE has risen substantially in many countries in recent decades, and this increase has been attributed mainly to changes in lifestyle, nutrition, and environmental factors.

Aim of the work: The aim of the work was toevaluate the serum level of Apelin in patients with atopic dermatitis and its correlation with disease severity in presence or absence of obesity.

Subjects: The present study included twenty patients with atopic dermatitis, twenty patients with atopic dermatitis and obesity, twenty patients with obesity only and twenty age and sex matched normal control subjects. Venous blood samples were taken for measurement of serum concentration of apelin and IgE.

Results: The results presented in our study demonstrate that a statistically significant difference in the level of apelin and statistically non-significant difference in level of IgE between four studied groups.

Conclusion: Our findings provided that apelin serum level increased with obesity and decreased with AD, with no correlation with both BMI and SCORAD which suggesting negative relation between apelin and severity of both diseases, also suggesting no association between severity of both diseases through our finding of no correlation between BMI and SCORAD.

Keywords: AD, apelin, IgE.

References

1. Ring J, Przybilla B, Ruzicka T (Eds). Handbook of atopic eczema. 2nd edition. Heidelberg: Springer 2006.

2. Bieber T. Atopic dermatitis. Ann Dermatol 2010; 22:125-37.

3. Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy ClinImmunol 2009; 124:1251-8.

4. Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy ClinImmunol 2010; 125:4-13.

5. Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 2006; 155:145-51.

6. Newson MJF, Pope GR, Roberts EM, Lolait SJ, O’Carroll AM. Stress-dependent and gender specific neuro regulatory roles of the apelin receptor in the hypothalamic–pituitary–adrenal axis response to acute stress. J Endocrinol 2013; 216:99–109.

7. Castan-Laurell I, Dray C, Attané C, Duparc T, Knauf C, Valet P: Apelin, diabetes, and obesity. Endocrine 2011; 40:1–9.

8. Kleinz MJ, Davenport AP. Emerging roles of apelin in biology and medicine. PharmacolTher 2005; 107:198–211.

9. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunol 2011; 11: 85-97.

10. Maenhaut N, Van-de Voorde J. Regulation of vascular tone by adipocytes. BMC Medicine 2011;16:9–25.

11. Principe A, Melgar-Lesmes P, Fernández-Varo G, Del Arbol LR, Ros J, Morales-Ruiz M, Bernardi M, et al. The hepatic apelin system: A new therapeutic for liver disease. Hepatol 2008; 48:1193-201.

12. Lee DK, Cheng R, Nguyen T, Fan T, Kariyawasam AP, Liu Y, et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000; 74:34–41.

13. Geha RS, Human IgE, J ClinImmunol 1984;109-120

14. Plebani M, Bemardi D, Basso D, Faggian D, Borghesan F. Measurement of specific immunoglobulin E intermethod comparison and standardization. ClinChem 1998; 44:9.

15. Machura E, Szczepanska M, Ziora K, Ziora D, Swietochowska E, Barc-Czarnecka M, et al. Evaluation of adipokines: Apelin, visfatin, and resistin in children with atopic dermatitis. Mediators Inflamm 2013; 2013: 760691.

16. MartinsTB, Bandhauer ME, Bunker AM, Roberts WL, Hill HR. New childhood and adult reference intervals for total IgE. J Allergy ClinImmunol 2014; 133: 589-91.

17. Hotze M, Baurecht H, Rodríguez E, Chapman-Rothe N, Ollert M, Fölster-Holst R, et al. Increased omalizumab efﬁcacy in ﬁlaggrin wild-type atopic dermatitis.Allergy 2014; 69: 132-5.

18. Jeong KY, Lee J, Li C, Han T, Lee SB, Lee H, et al. Juvenile Obesity Aggravates Atopic Dermatitis. Allergy Asthma Immunol Res 2015; 7: 69-75.

Corresponding Author

Sabrin Ebrahim Ahmed Ebrahim

Resident at Dermatology, Venereology and Andrology, Alexandria, Egypt

Phone no: +201229725759, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.