Title: Causative Organisms and Outcome in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Authors: Dr Smitha Nair P.G, Dr Achuthan .V, Dr Manoj. D.K, Dr Rajani.M, Dr Niyas Naseer, Dr Neethu Thambi
DOI: https://dx.doi.org/10.18535/jmscr/v4i10.117
BACKGROUND: Chronic obstructive pulmonary disease and its exacerbations are a major disease problem in Malabar area of Kerala associated with significant morbidity and mortality. AIMS AND OBJECTIVES: 1) To identify the causative organisms responsible for the infective exacerbations of chronic obstructive pulmonary disease. 2) To assess the clinical response to anti-microbial therapy based on sputum culture and sensitivity report. 3)To assess the influence of comorbid conditions in the outcome of chronic obstructive pulmonary disease MATERIALS AND METHODS: A hospital based, non interventional, prospective, study was conducted in the department of respiratory medicine, Pariyaram Medical College, Pariyaram, Kannur, Kerala, India. Study population was 100 consecutive adult COPD patients of either sex. Early morning sputum samples were collected in a sterile container and sent to microbiology department for Gram staining,Culture and sensitivity and acid fast bacilli staining. RESULTS: Among the total 100 patients studied most common age group was 60-69 years (42%).The mean age of study population was 65.6yrs.In this study, males constituted 97% and the rest of them were females. Sputum culture and sensitivity yielded bacterial growth in 67% of study sample.8% patients with fungal growth.25% yielded no growth. Out of 67% of study sample, 29 were streptococcus pneumoniae, which was the most common organism.15 were Hemophilus influenza, 6 were Moraxella catarrhalis and 6 were Klebsiella pneumonia. CONCLUSION: In this study, most of the acute exacerbations of COPD were caused by bacterial infections. The most common organisms isolated were streptococcus pneumoniae. KEYWORDS: Chronic Obstructive Pulmonary Disease, Sputum Culture And Sensitivity. 1. Mathers CD, LoncarD.Projections of global mortality and burden of disease from 2002 to2030.PLoS Med2006;3;e442. 2. 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