Title: Study of Coagulation Profile in Patients of Pregnancy Induced Hypertension-A Single Centric Prospective Study
Authors: Shweta Chaudhary, Seema Baxi
DOI: https://dx.doi.org/10.18535/jmscr/v4i10.112
Background: Present study was done to study the abnormalities in platelet, PT (prothrombin time) and APTT (activated partial thromboplastin time) in patients of PIH, to compare them with the results of normal pregnant females of 3rd trimester and to correlate them with the severity of PIH. Materials and Methods: 100 normotensive and 100 hypertensive 3rd trimester pregnant females formed the control and study group respectively. Platelet count, PT and APTT were performed by automatic analyzers. Results: Comparison between study and control group showed statistically significant (p<0.001) decrease in platelet count and increase in PT and APTT. Platelet count significantly decreased (p<0.05) with increasing severity except between gestational hypertension and mild preeclampsia. There is high prevalence of thrombocytopenia in preeclampsia (57%) and eclampsia (100%) cases. PT and APTT were prolonged only in cases of severe preeclampsia and eclampsia with platelet count <1 lac/cmm. Prolonged PT was seen in 28% and 37.5% cases and prolonged APTT in 2.8% and 25% cases of severe preeclampsia and eclampsia respectively. Conclusion: Significant thrombocytopenia is seen in PIH and degree increases with increasing severity. PT and APTT are also increased significantly in study group but do not differ with severity and are seen to be prolonged only in cases of thrombocytopenia. Mean PT and APTT fall in normal reference range in all groups, but increase from lower to upper normal limit as severity increases. Keywords: Pregnancy induced hypertension, PT, APTT, Platelet count. 1. DuttaDC.Text book of obstetrics.6th ed. Calcutta, India: New Central BookAgency; 2004:221-242. 2. Sibai BM, GabbeSG,NiebyJR,Simpson JL. Obstetrics: Normal and Problem Pregnan-cies. 3rdEd. New York: Churchill Livingstone; 1996: 935-991. 3. Leduc L, Wheeler JM, Kirshon B, Mitchell P, Cottan DB. Coagulation profile in severe preeclampsia.ObstetGynecol,1992 Jan;79(1):14-8. 4. Naaz A, PadugupatiS, Sarma, SushmaP. A Study on Coagulation Profile in Pregnancy Induced Hypertension Cases. IOSR Journal of Biotechnology and Biochem-istry. Sep. – Oct. 2015;1(6): 82-88. 5. Sharma SK, Philip J,Whitten CW, Padakandla UB, Landers DF. Assessment of changes in coagulation in parturients using thromboelastography. American society of Anaesthesiologistinc, 1999, vol. 90,385-390. 6. Prakash J, Pandey LK, Singh AK, Kar B. Hypertension in pregnancy: Hospital based study. J Assoc Physicians India 2006;54:273 7. Priyadarshini G, MohantyRR. Assessment of Coagulation Profile and its Correlation with Severity of Preeclampsia in Women of Odisha. International Journal of Physiology 2014;3 (1), 135-140. 8. Nirmala T, Kumar P. Study of coagulation profile in PIH. Indian Journal of Pathology and Oncology. 2015;2(1);1-6. 9. Lakshmi CV. Comparative Study of Coagulation Profile in Mild Pre-eclampsia, Severe Pre-eclampsia, and Eclampsia. Int J Sci Stud 2016;4(4):180-183. 10. ChauhanP,Rawat U, Bisht V, Purohit RC. Comparison of Coagulation Profile in Pre-Eclamptic and Eclamptic Patients with Normotensive Pregnant Patients. Journal of Evolution of Medical and Dental Sciences. 2014;3:3208- 3215. 11. Mohapatra S, PradhanBB, SatpathyU K, Mohanty A,PattnaikJ R. Platelet estimation: Its prognostic value in pregnancy induced hypertension. Indian J PhysiolPharmacol 2007; 51(2): 160-164. 12. Sarkar PD, Sogani S. Association of antithrombin-III and platelet count with pregnancy induced hypertension. Int J Reprod Contracept Obstet Gynecol. 2013;2:398-401. 13. Mirza AB. Coagulation Profiles in PIH –a) To Determine Coagulation Index to Distinguish Severe Preeclampsia from Normal Pregnancy b) To Assess the Correlation of Coagulation Parameters in Normal Pregnancy & in Varying Grades of Preeclampsia. International Journal of Science and Research. August 2015; 4 (8):387-90. 14. Kulkarni RD, Sutaria UD. Platelet count in toxaemias of pregnancy. J ObstetGynecol. India 1983; 33:321-25. 15. Mbanya D, TayouTagny C, Takoeta E, Mbu R, KaptueL.Factors associated with thrombocytopenia amongpregnant women in Cameroon. Sante2007; 17(4):213-7. 16. Joshi SR, Tekwani DT, Bihade A, Joshi R, Murley D. Study of coagulation profile in pregnancy induced hypertension. MedPulse – International Medical Journal. 2015; 2:299-302. 17. Metz J, Cincotta R, Francis M, DeRosa L, Balloch A. Screening for consumptive coagulopathy in preeclampsia.Int J GynaecolObstet, 1994 Jul; 46(1):3-9. 18. FitzGerald MP, Floro C, Siegel J, Hernandez E. Laboratory findings in hypertensive disorders of pregnancy. J Natl Med Assoc1996 Dec;88(12):794-8.Abstract
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