Title: Cytological Correlation of Benign Breast Diseases with Histopathology
Authors: Shilpa N, Shridevi S H
DOI: https://dx.doi.org/10.18535/jmscr/v4i10.74
Fine needle aspiration cytology (fnac) has become the popular diagnostic tool in preoperative assessment of breast masses and it has high diagnostic accuracy, sensitivity and specificity. The major goal of fnac is to differentiate benign lesion which is managed conservatively from the malignant one which need radical therapy.] Present study is undertaken to the distribution of the various benign breast diseases by cytology. Cytological with histopathological reports correlation was done to know the diagnostic accuracy of fnac. Materials and Methods: Present study included cytology of 88 breast lesions with histopathological correlation. It is retrospective and prospective study. Results are expressed in descriptive data, percentages and diagnostic accuracy was calculated by comparing cytological and histopathological reports. Results: The study included 88 breast cases, which were diagnosed as benign on cytology. Fibroadenoma was the commonest benign breast disease. The diagnostic accuracy of fine needle aspiration in diagnosing benign breast lesion is 96.6% with false negative rate of 3.4%. Discussion and Conclusion: In present study fibroadenoma is the most common benign breast disease, which is in accordance with previous studies. Maximum number of cases was in the age group between 20 to 29 years which correlates with the previous literature that benign breast disease are more common in young adults.The diagnostic accuracy and false negative rate of cytology in detecting benign breast masses is comparable to most of the previous studies. Keywords-Fibroadenoma, Fibrocystic disease, Phylloides tumour, Fine needle aspiration cytology, Mastitis. 1. Koss LG. The palpable breast nodule: a cost effectiveness and analysis of alternate diagnostic approaches: the role of the needle aspiration biopsy. Cancer 1993;72:1499-502. 2. Mendoza P, Lacambra M, Tan PH, Tse GM, Fine needle aspiration cytology of the breast: the non malignant categories, Pathol Res Int. 2011;2011:547580. doi: 10.4061/2011/5-47580. Available from https://www.hind-awi.com/journals/pri/2011/547580/ 3. Morris KT, Pommier RF, Morris A, Schmidt WA, Beagle G, Alexander PW, Toth-Fejel S, Schmidt J, Vetto JT. Usefulness of the triple test score for palpable breast masses. Archives of Surgery. 2001 Sep 1;136(9):1008-13. 4. Park IA, Ham EK . Fine needle aspiration cytology of palpable breast lesions. Histologic subtype in false negative cases. Acta Cytol 1997; 41:1131-8. 5. Schnitt SJ. Benign breast disease and breast cancer risk: morphology and beyond. Am J Surg Pathol 2003;27:836. 6. Dixon et al. Fine needle aspiration cytology in relationship to clinical examination and mammography in the diagnosis of a solid breast mass. British Journal of Surgery 1978; 71:593-596. 7. Ambedkar R K, Srinivasamurthy B C, Rani J. Cytological evaluation of benign breast lesions with histopathological correlation, Ind J Pathol Oncol 2016;3(1);7-10 8. 8.Ishikawa T, Hamaguchi Y,TanabeL M, False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions, Breast cancer 2007;14(4): 388–392. 9. O’Neil S, Castelli M, Gattuso P, Kluskens L, Madsen K, Aranha G. Fine-needle aspiration of 697 palpable breast lesions with histopathologic correlation. Surgery. 1997; 122(4): 824–28. 10. Zhang Qin, Nie Shigui, Chen Yuhua, Zhou Limei. Fine Needle Aspiration Cytology of Breast Lesions: Analysis of 323 Cases. The Chinese-German Journal of Clinical Oncology. 2004; 3(3): 172-74. 11. Mohammad AZ, Edino ST, Ochicha O, Alhassan SU. Value of fine needle aspiration biopsy in preoperative diagnosis of palpable breast lumps in resource- poor countries: a Nigerian experience. Annals of African Medicine. 2005; 4(1): 19-22. 12. Sahil I. Panjvani et al., Utility of Fine Needle Aspiration Cytology in the Evaluation of Breast Lesions, J Clin Diagn Res. 2013;7(12): 2777-2779Abstract
References