A Study of Serum Cystatin C in Chronic Kidney Disease Patients Undergoing Hemodialysis

Title: A Study of Serum Cystatin C in Chronic Kidney Disease Patients Undergoing Hemodialysis

Authors: Dr Tridip Kutum, Dr Nirmali Mattack, Dr Runi Devi, Dr Dibyaratna Patgiri

DOI: https://dx.doi.org/10.18535/jmscr/v4i10.46

Abstract

Introduction: CKD has become a major public health problem ⁽¹⁾. According to Dash and Agarwal (2006) ⁽²⁾ the prevalence of CKD in India accounts to around 0.8% of the total population which would be around 7.85 million of 1 billion population. In recent years, a novel endogenous marker of renal function, cystatin C, is emerging as a more sensitive marker than serum creatinine in estimating GFR ^(3,4,5,6).

Methods: Serum cystatin C, creatinine and blood urea nitrogen were estimated in patients of end stage kidney disease both before and after dialysis and also in the normal control individuals and were statistically analysed.

Observations & Results: The pre-dialysis and post-dialysis cystatin C were both significantly (p< 0.0001) higher than the normal control. Significant Correlation (p = 0.0214) between cystatin C and creatinine of the pre-dialysis test group and post dialysis group (p=0017) was observed. However no significant (p= 0.6359) correlation was found in the normal control group.

Conclusion: Considering the unique geographical location, ethnicity and dietary habits of the people of N.E. India, this study would be useful to determine if there are any significant changes in the levels of serum cystatin C in patients with chronic renal disease on haemodialysis in this part of the country and will also help the clinician in formulating the treatment protocol in such patients.

Keywords: Cystatin C, Creatinine, ESRD.

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Corresponding Author

Dr Tridip Kutum

Demonstrator, Dept. of Biochemistry

Tezpur Medical College, Tumuki, P.O.

Pin :- 784010 Tezpur, Assam

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