Title: Bacteriological Profile and Antimicrobial Susceptibility of Blood Culture Isolates from Tertiary Care Hospital, Navi Mumbai
Authors: Jyoti P.Sonawane, N.Kamath, Keertana Shetty, Rita Swaminathan
DOI: http://dx.doi.org/10.18535/jmscr/v4i10.35
Introduction: Blood stream infections (BSI) constitute a significant public health problem with increasing morbidity and mortality in hospitalized patients. Illnesses associated with blood-stream infections range from self-limiting infections to life threatening sepsis and require rapid and aggressive antimicrobial treatment. Again with the emergence of Multi-drug resistant organisms, there is increased risk of death in these patients. Aim & Objective: The present retrospective study was undertaken to know the profile of organisms causing bacteraemia with their antibiogram from clinically suspected cases of bacteraemia. Materials and Methods: Reports from the blood cultures submitted during the period of one year were analysed. 2994 blood culture samples were received to the microbiology laboratory. The bacterial isolates from positive cultures were identified by standard protocols and antimicrobial sensitivity patterns were determined by CLSI guidelines. Results: Positive blood cultures were obtained in 10.29 % (308/2994). Of 308 positive cultures, bacterial isolates were obtained in 286/ 308 (92.86%) and 22/308 (7.14%) were Candida spp. Of 286 bacterial isolates, Gram- negative bacteria accounted for 238 (83.22%) cases and Gram-positive were 48(16.78%) with predominance of Klebsiella spp. (22.38%) followed by Pseudomonas spp. (20.98%), Acinetobacter spp. (17.48%) an E.coli 32(11.19%). Among Enterobactericae, the high % of ESBL production was seen in Klebsiella aeruginosa (55.66%) and in E.coli (29.24%), with highest sensitivity to Imipenem (97.66%), Amikacin (60.16%) and Piperacillin-tazobactum (52.34%). All showed 100% sensitivity to colistin. Among non-fermenters, Imipenem sensitivity was (91.82%) followed by Piperacillin-tazobactum sensitivity (67.27%) & Amikacin sensitivity was (50%). Colistin showed (94.55%) sensitivity. 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