Title: Hypertriglyceridemia in Pregnancy Induced Hypertension
Authors: Dr V. Breetha, Dr K. Lavanya Kumari, Dr S.Sethupathy
DOI: https://dx.doi.org/10.18535/jmscr/v4i11.31
AIM: Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. Hormonal imbalance leading to altered lipid profile in serum is attributed to be one of the prime factors in etiopathogenesis of pregnancy-induced hypertension (PIH). So, the serum lipid profile in women with pregnancy induced hypertension and healthy pregnant women, in third trimester was evaluated in an attempt to study the etiopathogenesis and relationship of lipid levels to its complications, in the rural population attending our Medical College Hospital METHODS: This is a case control study comprising of 50 normal and 50 PIH cases in their third trimester of pregnancy. The serum Triglycerides (TG), Total cholesterol (TC), HDL-cholesterol (HDL-C), very low density lipoprotein (VLDL) and LDL- cholesterol (LDL-C) were evaluated and analyzed by auto analyzer. RESULTS: There was a significantly higher fasting triglycerides, total cholesterol, VLDL and LDL-C levels in PIH cases (P=<0.01), as compared to healthy pregnant women. CONCLUSION: Elevated serum total cholesterol and LDL cholesterol observed in PIH cases indicates abnormal lipid status and further studies are required to find out the implications of this on etiopathogenesis of PIH and foetal outcome in these cases. KEYWORDS: lipid profile, pregnancy-induced hypertension (PIH), Triglycerides (TG), Total cholesterol (TC), HDL-cholesterol (HDL-C),Very low density lipoprotein( VLDL) and LDL- cholesterol (LDL-C). 1. Kamath S. Hypertension in pregnancy. JAPL 2006; 54: 269–270 2. National high blood pressure education group report of National high blood pressure education program working group on high blood pressure in pregnancy. Am J OBSTETGYNECOL.2000;183(1):S1-S22. 3. cnossen, JS, van der post, JA. Mol, BW, khan,KS, meads, CA,terRiet, G. prediction of preeclampsia; a protocol for systemic review test accuracy.BMC pregnancy child birth 6 .29. 4. Robson SC. Hypertension and renal disea-se in pregnancy, In: Dewhurst’s Textbook of Obstetrics and Gynaecology for post graduates, Ed. Edmonds DK., 6th edition, Blackwell Science Ltd, New York 1999; 167–169. 5. Singh U,Yadav S, Mehrotra S, Natu SM, Kumari K, Yadav YS. Serum Lipid Profile in Early Pregnancy as a Predictor of Preeclampsia. Int J Med Res Rev 2013; 1(2):56-62. 6. Amandeep Singh Kaloti, Charanjeet Kaur, R. K. Goel, S.Jha. Study of lipid profile trends in women of pregnancy induced hypertension cases in a rural setup. Journal of Evolution of Medical and Dental Sciences. 2013; 2(13):2024-31. 7. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ. Lipoprotein subfraction concentrations in pre eclampsia: Pathogenic parallels to athero-sclerosis. Obstet Gynecol 1997; 89: 403-8. 8. Kokia E, Barkai G, Reichman B, Segal P, Goldman B, Mashiach S. Maternal serum lipid profile in pregnancies complicated by hypertensive disorders. J. Perinat. Med. 1990; 18: 473-78 9. Glueck CJ, Pallet RW, Scheel D. Effects of oestrogenic compounds on triglyceride kinetics. Metabolism 1975; 24: 537–545. 10. Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens 2004; 17(7): 574–581. 11. Cekmen MB, Erbagci AB, Balat A, Duman C, Maral H, Ergen K, Osden M, Balat O, Kuskay S. Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension. Clin Biochem 2003; 36(7): 575–578. 12. Mikhail MS, Basu J, Palan PR, Furgiusle J, Romney SL, Anyaegbunam A. Lipid profile in women with preeclampsia: relatioship between plasma triglycerides levels and severity of preeclampsia. J Assoc Acad Minor Phys 1995; 6(1): 43–45. 13. Kokia E, Barkai G, Reichmah B, Segal P, Goldman B, Mashiach S. Maternal serum lipid profile in pregnancies complic-ated by hypertensive disorders. J Perinat Med (Germany) 1990; 18(6): 473–478. 14. Kaaja R, Tirkkanen MJ, Vinnakka L, Ylikorkala O. Serum lipoproteins, insulin and urinary prostanoid metabolites in normal and Hypertensive pregnant women. Obstet Gynecol 1995; 85(3): 353–356. 15. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ. Lipoprotein subfraction concentrations in preeclam-psia: pathogenic parallels to Atheroscle-rosis. Obstert Gynecol 1991; 89(3): 403–408. 16. Gratacos E, Casals E, Gomez O, Llurba E, Mercador I, Cararach V, Cabero L. Increased susceptibility to low density lipoprotein oxidation in women with a history of preeclampsia. British Journal of Obst Gynae 2003; 110(4): 400–440. 17. Wakatsuki A, Ikenoue N, Okatani Y, Shinohara K, Fukaya T. Lipoprotein particles in preeclamsia: Sucsceptibility to oxidative modification. Obstet Gynecol 2000; 96(1): 55–59.] 18. Lorentsen B, henriksen T. Plasma lipids and vascular dysfunction in preeclampsia. Semin Reprod Endocrinol 1998; 16(1): 33-39.Abstract
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