Title: A Comparative Study of Inj. Labetalol & Oral Nifedipine in Severe Hypertension in Pregnancy
Authors: Dr Rinkesh Meena, Dr Dharmraj Meena
DOI: https://dx.doi.org/10.18535/jmscr/v4i11.20
PIH is a form of high blood pressure in pregnancy. PIH is also called toxemia or preeclampsia. It occurs most often in young women with a first pregnancy. The proposed study was clinical trial of comparison of oral administration of tab. Nifedipine and inj labetalol in case of severe PIH. Criteria for inclusion in the study were women with blood pressure more than 160/110mm hg. In nifedipine group 76% patients had a DBP in the range of 110-120mmHg, of these 32% responded favourably but in remaining cases other drugs was added. Similarly in Labetalol group 72% had DBP in the range of 110-120 mmHg, of which 60% responded to labetalol. It appears that inj Labetalol is more effective in lowering the diastolic BP in severe PIH as compared to Nifedipine. Further fewer patients needed other anti hypertensive drug in Labetalol group. Labetalol group had favorable parameters in all aspects. However larger studies are required to establish the superiority of inj Labetalol in PIH. KEYWORDS:- DBP (Diastolic Blood Pressure), SBP (Systolic Blood Pressure) 1. Landheimer MD, Katz AI : Currenct concepts . Hypertension in pregnancy. N. Engl J Med 313: 675-680, 1985. 2. Pritchard JA, MacDonald PC, Gant N: Hypertensive disorder in pregnancy. In Williams Obstetrics Ed. 17, Norwalk, CT Appleton Century Crofts, p. 525.1985. 3. Eastman, NJ and Hellmann LN: Williams Obsterics, 12th ed., 1971. 4. Coonrod DV, Hickok DE, Zhu K. et al. Risk factors for preeclampsia in twin pregnancies: a population based cohort study Obstet Gynecol :85:645-50. 1995. 5. Redman CWJ, Bellin LJ and Sonnar J: Treatment of hypertension in pregnancy with methyldopa. Blood Pressure control& side effects. Br. J. Gynaec 84:419, 1984. 6. Long PA, Oats JN, Preeclampsia in twin pregnancy- severity and pathogenesis. Aust. NZJ Obtet. Gynaecol 27:1-5, 1987. 7. Santema J G, Koppelaar I, Wallenburg HC. Hypertensive disorders in twin pregnancy. Eur J. Obstet Gynecol Report Biol: 58:9-13, 1995. 8. Kuo HH, Yang JM, Wang KG. Preecla-mpsia in multiple pregnancy. Chung Hua I Hsueh Tsa. Chih (Taipei) (Chin Med J) 55:392-5,1995. 9. Coonrod DV, Hickok DE, Zhu K. et al. Risk factors for preeclampsia in twin pregnancies: a population based cohort study Obstet Gynecol :85:645-50. 1995. 10. Macgillivray, et at Brit. J. Obstet Gynecol. 65:536, 1968. 11. Mauricaeu F: Quoted from Blood Presure proteinuria and oedema in pregnancy. New York p.28, 1964. 12. Hansen JP: Older maternal age and preg-nancy outcome : A review of literature. Obstet Gynarcol Survey 41: 726, 1986. 13. Pepatsonis DM, Lok CA, Bos JM et. Al Calcium channel blocker in management of preterm labour and hypertension in pregnancy Eur. J. Obstet. Gynaecol. Report Biol. 2001, 97:122-140. 14. Grossman E, Messerli FH, Grodzicki T, Kowey P 1996 “Should a moratorium be placed on sublingual nifedipine capsule given for hypertensive emergencies” JAMA 276, (16) 1328-31. 15. Sibai BM,Barton JR,Expectent manage-ment of severe preeclampsia remote from term,patient selection, treatment, and delivery indication.Am J Obstet Gynecol 2007;196-514e-514e9.Abstract
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