Title: Does Endometrial Injury Guided Hysteroscopy Improve Implantation Rate of Frozen-Thawed Embryo Transfer?
Author: Ashraf Hany Abdelrahman
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.118
Abstract
Implantation failure is one of the most important factors limiting success in IVF –ICSI treatment. The majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women who failed to implant before, on the other hand some studies failed to find a beneficial response.
0bjective: The purpose of our trial was to explore whether endometrial injury guided hysteroscopy in a cycle (luteal phase) prior to frozen-thawed (FT) blastocyst transfer cycles would improve implantation rate.
Materials and Methods: We conducted a prospective randomized controlled trial of 90 consecutive women at Shatby IVF-ICSI unit at the university hospital and Madina IVF-ICSI center. All women were undergone frozen-thawed (FT) blastocyst transfer cycles. Women in the test group underwent endometrial injury guided hysteroscopy in the cycle (luteal phase) preceding FT blastocyst transfer cycle. Primary outcomes were implantation and chemical pregnancy rates.
Results: 45 subjects who underwent endometrial injury (EI) guided hysteroscopy were compared with 45 control group which did not include any uterine manipulation. There were no significant differences in baseline and cycle characteristics between two groups. Chemical (57.8% versus 31.1%) and implantation (42.2% versus 15.6%), rates were significantly higher in the test group compared to the control group
Conclusion: Based on results ofthis study, local injury to endometrium guided hysteroscopy in the cycle preceded the FT blastocyst transfer cycle had promising results on implantation and pregnancy rates.
Keywords: Endometrial injury, Frozen-thawed blastocyst transfer, Implantation rat.
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