Title: Assessment, Monitoring and Reporting of Adverse Drug Reactions Due to Polypharmacy
Authors: Dr M Sureswara Reddy, K Thirumala Naik, L Kavya, J Harini, K Sirisha, A Shiva, M Venkata Subbaiah
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.102
Abstract
Poly-pharmacy significantly increases the likelihood of adverse reactions to drugs, risk of hospitalization and medication errors related to drugs. It depends on the number of drugs, the disease and patient related factors. Poly-pharmacy is a major risk factor for severe adverse drug reactions (ADR’S) and is associated with increased risk of mortality. The main aim of this study was to assessment and monitoring of polypharmacy leading to adverse drug reaction. A Prospective observational study was carried out in Rajiv Gandhi institute of medical sciences (RIMS), a 750 bedded tertiary care teaching hospital, Kadapa, for the period of 7 months in the all deportments of hospital. A total of 448 cases of polypharmacy were identified, among that males were 246 and females were 202. Out of 448 cases, 252 patients were major polypharmacy and 196 were minor polypharmacy. Among 114 ADRs, 22.80% from MICU, 31.57% from MMW, 27.19% from FMW, 10.52% from PSY and 7.89 from DVL, The identified ADRs were reported to physician and the causality assessment was done for 114 ADRs by using Naranjo’s scale. According to Naranjo’s scale 24 (60.28%) ADRs were definitely, 52 (57.42%) were probable, 38 (81.37%) were possible. The role of pharmacists is important to continually educate but also to have access to complete patient records. So they could look at all of the medications that may be given to the patient for better patient care.
Keywords: ADR’s, Poly pharmacy, Assessment, Monitoring and Outcomes.
References
1. Linda R Tulner , Indeborg MJA Kuper, Suzanne V Rank fort, Jos PCM Van campen, cornelis HW KoKs, Desiderius PM Brandjer, Jos H Beijnen. Disscrepanciesin reported drug use in geriatric out patients: Relevance to advers events and drug drug intractions J AMJOpharm 2009:7(2):
2. Nimmy N John, RH Udupi, KM Binnu. Incidance of polypharmacy induced drug intractions in a tertiary care hospital. Intrnational Journal of Pharmaceuticals and Research 2012:3(7):2119-21
3. Parthasarathi G, Karin N, Hansen, Milap N. A text book of clinical pharmacy practice. P. 8-97
4. Akshaya Sreekanth, G Sireesha Assesment on the prevalence of polypharmacy in Urban population. Inventi Impact: Pharmacy Practice 2012:4:2229-4201
5. Shamna M, Dilip C, Ajmal M, Linu Mohan P, C CP Jafer, Yahiya Mohammed. A Prespective study on Adverse Drug Reaction of Anti Biotics in tertiory care hospital J. JSPS 2015:6 (4): 1-6
6. Subhatara Swamy. Bhanu Prakash, Prathiba Ndigi, Murali Mohan and Manjula Shetty. Profile of suspect ADR in a tertiory teaching care hospital J Pharmacol Clin Toxicol 1005:141:1-5
7. Lobo et al Adverse Drug Reaction Monitoring: support for Pharmacov-igilance at a teaching care hospital in Northen Brazil, BMC Pharmacology and Toxicology 2013: 14: 5. http://dr. doi. Org /10. 1186/ 2050-6511-14-5.