Possible Role of CPK-MB in the Early Detection of Alcohol Related Cardiac Damage

Title: Possible Role of CPK-MB in the Early Detection of Alcohol Related Cardiac Damage

Authors: Dr Paramveer Singh, Dr Sanjiv S. Kale

DOI: https://dx.doi.org/10.18535/jmscr/v4i12.65

Abstract

INTRODUCTION

Alcohol: A potent psychoactive drug, causes acute and chronic changes in all organ systems. Alcohol consumption in large quantities over a long period of time causes cardiac morbidity. Association between excessive consumption and congestive cardiomyopathy has long been known. ⁽¹⁾Patients consuming > 90 g of alcohol a day for > 5 years are at risk for the development of asymptomatic Alcoholic Cardiomyopathy.⁽²⁾ CPK-MB is a sensitive, specific and cost effective test used in diagnosis of acute myocardial infarction.⁽³⁾⁽⁴⁾Few studies, in alcoholics show raised levels due to chronic myocardial damage.

References

1. Bridgen W, Robinson J. Alcoholic heart muscle disease. Br Med J 1964;ii:1283-9

2. Mariann R. Piano. Alcoholic cardiomyo-pathy: Incidence, Clinical Characteristics, and Pathophysiology. Chest. 2002;121(5): 1638-1650. doi:10.1378/chest.121.5.1638

3. A. F. Smith et al. Creatine kinase MB isoenzyme studies in diagnosis of myocar-dial infarction. Br Heart J, 1976, 38, 225-32

4. Konttinen and Somer.BMJ, 1973;1:386

5. George E. Burch, Nicholas P. DePasquale. Alcoholic cardiomyopathy The American Journal of Cardiology, Vol 23, Issue 5, 723-31

Corresponding Author

Dr Paramveer Singh

Flat No. 8, Rohideshwar CHS, Plot No. 6, Gurudwara Marg, Sec 19,

Nerul East, Navi Mumbai – 400706, Maharashtra

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Mobile: 7506400785