A Hospital Based Study on Serum Uric Acid and Renal Function in Hypertensive Subjects of Northeast India

Title: A Hospital Based Study on Serum Uric Acid and Renal Function in Hypertensive Subjects of Northeast India

Authors: Dr Nirmali Mattack, Dr Elteza Tahziba Jahir, Dr Tridip Kutum

DOI: https://dx.doi.org/10.18535/jmscr/v4i12.55

Abstract

This is a case control study which involved 50 hypertensive subjects and 50 normotensive subjects and was carried out in Gauhati Medical College and Hospital. Subjects having systolic BP more than 140mm Hg and Diastolic BP more than 90mm Hg were considered hypertensive. Serum uric acid, urea and creatinine were evaluated in both the case and control groups in VITROS 5600. eGFR was estimated using online calculator based on the UK CKD eGuide on the Renal Association website. Statistical evaluation was done using unpaired student t test and Pearson correlation. The case group had an extremely significant high serum uric acid (p<0.0001) serum urea(p<0.0001) and serum creatinine (p=0.0009) compared to the control group, whereas eGFR was extremely significantly lower in the case group(p<0.0001). A significant negative correlation (r=-0.641, p<0.0001) was found between serum uric acid and eGFR. This study suggests that uric acid might indeed have a role in mediating hypertension via various mechanisms, and that renal function is closely associated with serum uric acid levels. Therefore, for screening of hypertension, periodic assessment of serum uric acid might be considered.

Keywords: Hypertension, uric acid, urea, creatinine, Egfr.

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Corresponding Author

Dr Nirmali Mattack

C/O Mr. M.S Khaund, Flat A1, Block 3A,

Regent Paradise, Bhetapara, Guwahati-28 INDIA

Email: This email address is being protected from spambots. You need JavaScript enabled to view it., Telephone No. 919531004326