Evaluation of Oral Pregabalin Premedication for Attenuation of Pressor Response during Laryngoscopy and Endotracheal Intubation

Title: Evaluation of Oral Pregabalin Premedication for Attenuation of Pressor Response during Laryngoscopy and Endotracheal Intubation – A Randomised Clinical Study

Authors: Gagandeep Singh, Pavan Dhulkhed, Indrajit Gupta, V.K.Dhulkhed, Bilal Mohammad, Tushar Munnoli

DOI: https://dx.doi.org/10.18535/jmscr/v4i12.37

Abstract

Background & Objective: This clinical study was designed to evaluate and compare single preoperative dose of pregabalin to placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side effects.

Methods: 60 ASA I and II patients undergoing elective surgical procedures were randomly selected and divided into 2 groups of 30 each. Group A received placebo and Group B received pregabalin 150mg orally 1hour before induction. The patients were compared for hemodynamic changes before the start of surgery, after induction, 1, 3, 5 & 10 minutes after intubation. Additionally fentanyl requirement during surgery and analgesia requirement during first 24 hrs of post operative period was also compared.

Result: Preoperative sedation levels were higher with pregabalin premedication. Oral pregabalin significantly attenuated the heart rate(HR), systolic blood pressure(SBP),diastolic blood pressure (DBP) and mean arterial pressure( MAP) due to laryngoscopy and endotracheal intubation.

Conclusion: The present study shows that single oral dose of 150mg pregabalin given 1hr before surgery attenuated the pressor response to tracheal intubation in adults, has adequately sedated the patients and was devoid of side effects in the given dose.

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Corresponding Author

Gagandeep Singh

Department of Anaesthesiology

Krishna Institute of Medial Sciences, Karad, Maharashtra