Title: Dermatofibrosarcoma Protuberans over Anterior Abdominal Wall: A Case Report
Authors: Dr Arnab Sarkar, Dr Amul Bhedi, Dr Sushil Damor
DOI: https://dx.doi.org/10.18535/jmscr/v4i12.33
This is the case of a 66 year old female presented with a swelling over left anterior abdominal wall since five years. Further examination of the morphology of the resected surgical specimen, histological and immunohistochemical studies confirmed it to be a dermatofibrosarcoma protuberans over the anterior abdominal wall. It was successfully managed by a wide local excision with an excellent result and a high degree of patient satisfaction was achieved. Though a rare clinical entity, this tumor has chances of high recurrence, and so it should be borne in mind while making a diagnosis and during its long term follow- up. Keywords: CD34, Dermatofibrosarcoma protuberans, Imatinib mesylate, Mohs’ microscopic surgery, Soft-tissue sarcoma. 1. Stojadinovic A, Hoos A, Karpoff HM, Leung DH, Antonescu CR, Brennan MF, et al. Soft tissue tumours of the abdominal wall: Analysis of disease patterns and treatment. Arch Surg. 2001;136:70–9 2. Weiss SW, Goldblum JR, Enzinger and Weiss’s soft tissue tumors. $th ed, Mosby, 2001. P 491- 507 3. Mc Peak CJ, Cruz T, Nicastri AD. Dermatofibrosarcoma protuberans: An analysis of 86 cases- five with metastases. Ann Surg. 1967;166:803–16 4. Khatri VP, Galante JM, Bold RJ, Schneider PD, Ramsamooj R, Goodnight JE Jr. Dermatofibrosarcoma protuberans: Reappraisal of wide local excision and impact of inadequate treatment. Ann Surg Oncol.2003;10:1118–22 5. Sjöblom T, Shimizu A, O'Brien KP, Pietras K, Dal Cin P, Buchdunger E, et al. Growth inhibition of dermatofibrosarcoma protuberans tumours by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis. Cancer Res. 2001;61:5778–83 6. Kiuru-Kuhlefelt S, El-Rifai W, Fanburg-Smith J, Kere J, Miettinen M, Knuutila S. Concomitant DNA copy number amplific-ation at 17q and 22q in dermatofibrosarcoma protuberans. Cytogenet Cell Genet.2001; 92:192–5 7. McArthur GA, Demetri GD, van Oosterom A, Heinrich MC, Debiec-Rychter M, Corless CL, et al. Molecular and clinical analysis of locally advanced dermatofibro-sarcoma protuberans treated with imatinib: Imatinib target exploration consortium study B2225. J Clin Oncol. 2005;23:866–73. 8. Loghdey M.S., Varma S., Rajpara S.M., Al-Rawi H., Perks G., Perkins W. Mohs micrographic surgery for dermatofibrosa-rcoma protuberans (DFSP): a single-centre series of 76 patients treated by frozen-section Mohs micrographic surgery with a review of the literature. J Plastic Reconstr Aesthet Surg.2014;67(10):1315–1321 9. Suit H., Spiro I., Mankin H.J., Efird J., Rosenberg A. Radiation in management of patients with dermatofibrosarcoma prot-uberans. J Clin Oncol. 1996;14(8):2365–2369. 10. Dagan R, Morris CG, Zlotecki RA, Scarborough MT. Radiotherapy in the treatment of DFSP. Am J Clin Oncol 2005;28:537-9. Dr Arnab Sarkar A-288, Somnath Nagar, Nr. Ravi Park, Tarsali, Vadodara- 390009 Email: This email address is being protected from spambots. You need JavaScript enabled to view it.Abstract
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