Title: An Unaccustomed Presentation of Besnier-Boeck-Schaumann Disease

Authors: Dr Vani Raj I, Dr Suresh Raghavan

 DOI: https://dx.doi.org/10.18535/jmscr/v11i10.11

Abstract

Eliminating other potential causes of granulomatous inflammation helps to diagnose the mysterious sarcoidosis. All clinicians face a diagnostic dilemma because of the clinical polymorphism and the multisystemic sarcoidosis symptoms. After the lungs, the skin is the organ most frequently impacted by sarcoidosis. Before, during, or after systemic involvement, dermatological symptoms can occur, and the kind of skin lesion can have a bearing on the prognosis. Additionally, compared to a biopsy of visceral organs, a skin lesion biopsy is easier to perform and less intrusive. Therefore, there are some instances in which cutaneous symptoms can help with the diagnosis and outlook of a systemic illness. A high index of clinical suspicion is needed for early diagnosis and timely management, which can improve the quality of life for those patients and reduce morbidy and mortality due to this disease. This article has emphasised the prevalence, clinical characteristics, and treatment of the common skin lesions of sarcoidosis.

References

  1. Jain, R., Yadav, D., Puranik, N., Guleria, R., & Jin, J.-O. (2020, April 10). Sarcoidosis: Causes, diagnosis, clinical features, and treatments. Journal of clinical medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230978/
  2. Ungprasert, P., Ryu, J. H., & Matteson, E. L. (2019a, August 2). Clinical manifestations, diagnosis, and treatment of sarcoidosis. Mayo Clinic proceedings. Innovations, quality & outcomes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713839/
  3. https://jmscr.igmpublication.org/home/index.php/archive/137-volume-05-issue-04-april-2017/2070-sarcoidosis-a-great-masquerader-case-report
  4. https://www.emjreviews.com/dermatology/article/scalp-sarcoidosis-with-systemic-involvement-a-case-report-and-literature-review/#:~:text=Diagnosis%20of%20sarcoidal%20alopecia%20is,indistinguishable%20from%20pseudopelade%20of%20Brocq
  5. Hutchinson J. Anomalous disease of the skin of the fingers: Case of livid papillary psoriasis. Illus. Clin. Surg. 1877;1:42–43. [Google Scholar]
  6. Gupta S.K. Sarcoidosis: A journey through 50 years. Indian J. Chest Dis. Allied Sci. 2002;44:247–254. [PubMed] [Google Scholar]
  7. Hunninghake G. Statement on sarcoidosis. Am. J. Respir. Crit. Care Med. 1999;160:736–755. [PubMed] [Google Scholar]
  8. Baughman R.P., Teirstein A.S., Judson M.A., Rossman M.D., Yeager H., Jr., Bresnitz E.A., DePalo L., Hunninghake G., Iannuzzi M.C., Johns C.J., et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am. J. Respir. Crit. Care Med. 2001;164:1885–1889. Doi: 10.1164/ajrccm.164.10.2104046. [PubMed] [CrossRef] [Google Scholar]
  9. Li C.-W., Tao R.-J., Zou D.-F., Li M.-H., Xu X., Cao W.-J. Pulmonary sarcoidosis with and without extrapulmonary involvement: A cross-sectional and observational study in china. BMJ Open. 2018;8:e018865. Doi: 10.1136/bmjopen-2017-018865. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  10. Siltzbach L.E., James D.G., Neville E., Turiaf J., Battesti J.P., Sharma O.P., Hosoda Y., Mikami R., Odaka M. Course and prognosis of sarcoidosis around the world. Am. J. Med. 1974;57:847–852. Doi: 10.1016/0002-9343(74)90160-0. [PubMed] [CrossRef] [Google Scholar]
  11. Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., Kambouchner M., Valeyre D., Chapelon-Abric C., Debré P., et al. The immune paradox of sarcoidosis and regulatory t cells. J. Exp. Med. 2006;203:359–370. Doi: 10.1084/jem.20050648. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  12. Zissel G. Cellular activation in the immune response of sarcoidosis. Semin. Respir. Crit. Care Med. 2014;35:307–315. Doi: 10.1055/s-0034-1376861. [PubMed] [CrossRef] [Google Scholar]
  13. Iannuzzi M.C., Rybicki B.A., Teirstein A.S. Sarcoidosis. N. Engl. J. Med. 2007;357:2153–2165. Doi: 10.1056/NEJMra071714. [PubMed] [CrossRef] [Google Scholar]
  14. Prior C., Knight R.A., Herold M., Ott G., Spiteri M.A. Pulmonary sarcoidosis: Patterns of cytokine release in vitro. Eur. Respir. J. 1996;9:47–53. Doi: 10.1183/09031936.96.09010047. [PubMed] [CrossRef] [Google Scholar]
  15. Peros-Golubicic T., Ljubic S. Cigarette smoking and sarcoidosis. Acta Med. Croat. 1995;49:187–193. [PubMed] [Google Scholar]
  16. Siltzbach L.E. Current thoughts on the epidemiology and etiology of sarcoidosis. Am. J. Med. 1965;39:361–368. Doi: 10.1016/0002-9343(65)90205-6. [PubMed] [CrossRef] [Google Scholar]
  17. Arkema E.V., Cozier Y.C. Epidemiology of sarcoidosis: Current findings and future directions. Ther. Adv. Chronic Dis. 2018;9:227–240. Doi: 10.1177/2040622318790197. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
  18. Arkema E.V., Grunewald J., Kullberg S., Eklund A., Askling J. Sarcoidosis incidence and prevalence: A nationwide register-based assessment in sweden. Eur. Respir. J. 2016;48:1690–1699. Doi: 10.1183/13993003.00477-2016. [PubMed] [CrossRef] [Google Scholar]
  19. Bresnitz E.A., Strom B.L. Epidemiology of sarcoidosis. Epidemiol. Rev. 1983;5:124–156. Doi: 10.1093/oxfordjournals.epirev.a036255. [PubMed] [CrossRef] [Google Scholar]

Corresponding Author

Dr Vani Raj I

Junior Resident, Department of General Medicine, Govt. T.D Medical College, Alappuzha, Kerala, India