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Category: Volume 11 Issue 04 April 2023
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Title: An Overview of Factors Responsible for Recurrent Pregnancy Loss

Authors: Dr Ranjana Rawat, Dr Pawan Kumar Sharma, Dr Sheela Sharma, Dr Pawan Arun Kulkarni, Dr Sukanta Bandyopadhyay

 DOI: https://dx.doi.org/10.18535/jmscr/v11i4.14

Abstract

Many couples attempt to get pregnant but experience recurrent miscarriage, also referred to as recurrent pregnancy loss. It has become difficult to understand the reason even after numerous investigations and hence, it can be difficult for both patients and clinicians. It has been studied that the most frequent reason for spontaneous loss is spontaneous foetal aneuploidies, especially in the first stage of pregnancy. To prevent tests or treatments that are unnecessary or have not been proven to be beneficial, studies show that it is critical to use a methodical and evidence-based strategy to testing and management. A crucial component of the management of couples with recurrent miscarriage is the specialized clinic services and psychological assistance. Also, there are many case studies which show that losses caused by de novo foetal aneuploidies happen to women who experience sporadic and recurrent losses at about the same rates, some couples who experience recurrent pregnancy loss have additional genetic factors that are linked with them, while others have nongenetic causes. Genetic testing of the foetuses from couples who have experienced two or more miscarriages could help identify the root cause and inform patients about their chances of having a healthy baby in the future. The present review emphasizes on the various aspects of recurrent pregnancy loss. It also deals with the factors which aid in causing the same. In addition, it is an examination of the relation between pregnancy and immune factors.

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Corresponding Author

Ranjana Rawat

Department of Biochemistry Rama Medical College, Hospital & Research Centre Mandhana, Kanpur, Uttar Pradesh, India