Title: Mucinous Cystic Neoplasm of Pancreas: A Rare Case Report

Authors: Dr Zini Chaurasia, Dr Cheta Singh

 DOI: https://dx.doi.org/10.18535/jmscr/v11i4.05

Abstract

Mucinous cystic neoplasms of the pancreas are defined by the world health organization (WHO) as cystic epithelial neoplasms that occur almost exclusively in women. Mucinous cystic neoplasms account for 5-7% of primary pancreatic tumors, with a female-to-male ratio of 20:1 and with a mean age between 40 and 50 years. Approximately 70–90% of mucinous cystic neoplasms arise in the body or tail of the pancreas.

Case Description: A-38-years female patient presented with epigastric pain for 3 months. There was no palpable mass. Computer tomography revealed a well-defined thick-walled, cystic lesion in the body and tail region of the pancreas measuring 50x50x45 mm. This mass was extending into the lesser sac and closely abutting the lesser curvature of the stomach. The radiological impression was a pancreatic pseudocyst. Ultrasound guided-FNAC was performed but it was inconclusive. The mass was excised with the tail of the pancreas and spleen. The specimen was sent for Histopathological examination for confirmation of diagnosis.

Conclusion: Mucinous cystic neoplasm is a rare entity and it is very important to distinguish it from the Intrapapillary ductal neoplasm and solid pseudopapillary neoplasm of the pancreas. The presence of ovarian stroma with focal mucinous lining helps to clinch the diagnosis and one should carefully look for dysplasia.

References

  1. Murakami Y, Uemura K, Ohge H. Intraductal papillary-mucinous neoplasms and mucinous cystic neoplasms of the pancreas differentiated by ovarian-type stroma. Surgery. 2006;140:448–453.
  2. Mino-Kenudson M, Ban S, Deshpande V.Mucinous cystic neoplasm:unique ovarian stroma but heterogeneous epithelial lining. Lab Invest. 2008; 68:277A.
  3. Suzuki Y, Atomi Y, Sugiyama M, Isaji S, Inui K, Kimura W, Sunamura M, Furukawa T, Yanagisawa A, Ariyama J, Takada T, Watanabe H, Suda K. Cystic neoplasm of the pancreas: a Japanese multiinstitutional study of intraductal papillary mucinous tumor and mucinous cystic tumor. Pancreas. 2004;28:241–246
  4. Thompson LD, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999;23:1–16.
  5. Wilentz RE, Albores-Saavedra J, Hruban RH. Mucinous cystic neoplasms of the pancreas. Semin Diagn Pathol. 2000;17:31–42
  6. Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Kloppel G. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol. 1999;23:410–422.
  7. Kloppel G, Luttges J. WHO-classification 2000: exocrine pancreatic tumors. Verh Dtsch Ges Pathol. 2001;85:219–228. 
  8. Volkan Adsay, N. Cystic lesions of the pancreas. Mod Pathol 20, S71–S93 (2007).
  9. van den Berg W, Tascilar M, Offerhaus GJ, Albores-Saavedra J, Wenig BM, Hruban RH etal. Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. Mod Pathol. 2000;13:86–91
  10. Lee WA. Mucinous cystadenoma of the pancreas with predominant stroma creating a solid tumor. World J Surg Oncol. 2005;3:59. Published 2005 Sep 7. doi:10.1186/1477-7819-3-59.
  11. Hwang J, Kim YK, Min JH, Jeong WK, Hong SS, Kim HJ (2018) Comparison between MRI with MR cholangiopancreatography and endoscopic ultrasonography for differentiating malignant from benign mucinous neoplasms of the pancreas. Eur Radiol 28(1):179–187
  12. Nilsson LN, Keane MG, Shamali A, Millastre Bocos J, Marijinissen van Zanten M, Antila A et al (2016) Nature and management of pancreatic mucinous cystic neoplasm (MCN): a systematic review of the literature. Pancreatology 16(6): 1028–1036.
  13. Griffin JF, Page AJ, Samaha GJ, Christopher A, Bhaijee F, Pezhouh MK et al (2017) Patients with a resected pancreatic mucinous cystic neoplasm have a better prognosis than patients with an intraductal papillary mucinous neoplasm: a large single institution series. Pancreatology 17(3):490–496.
  14. Greer JB, Ferrone CR (2016) Spectrum and classification of cystic neoplasms of the pancreas. Surg Oncol Clin N Am 25(2):339–350.
  15. Berger AW, Seufferlein T, Kleger A (2017) Cystic pancreatic tumors: diagnostics and new biomarkers. Chirurg 88(11):905–912.
  16. Esposito I, Schlitter AM, Sipos B, Klöppel G (2015) Classification and malignant potential of pancreatic cystic tumors. Pathologe 36(1):99–112.

Corresponding Author

Dr Zini Chaurasia

Senior Resident, Department of Pathology, Dr Baba Sahab Ambedkar Medical College and Hospital