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Category: Volume 10 Issue 02 February 2022
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Title: Study of serum uric acid level in chronic liver disease and its correlation with Child-Turcotte-pugh score and platelet indices

Authors: Dr Manomenane M, Dr Viswanathan K N, Dr Badrinath A K, Dr Karthik J, Dr Reenaa Mohan

 DOI: https://dx.doi.org/10.18535/jmscr/v10i2.19

Abstract

Background: Increased blood uric acid levels in chronic liver disease (CLD) promote endothelial dysfunction, insulin resistance, oxidative stress, and systemic inflammation, all of which are key risk factors for liver disease development.

Objective: The purpose of this study was to see correlation between blood uric acid levels with Child-Turcotte-Pugh (CTP) score and platelet indices.

Methods: A hospital-based cross-sectional research was conducted on individuals with CLD who were above the age of 18. A total of 54 people were included in the study. The levels of uric acid in the blood, as well as the CTP score and platelet indices, were assessed.

Results: Among 54 patients most patients belonged to CTP class C (51.85%) followed by CTP class B (40.74%) CTP class A (7.4%). The most prevalent cause of CLD (59.25%) is alcoholic liver disease. The average blood uric acid level in the CTP class A, B, C were 3.75 ± 1.5, 4.2 ± 2.29 and 6.26 ± 2.92 respectively andclinically important, showing positive correlation uric acid and CTP score (r value: 0.347, P- value 0.001). It was also found that platelet distribution width increases with increasing serum uric acid level.

Conclusion: A rise in serum uric acid level coincides with an increase in Child Pugh score, implying that uric acid estimation can be a viable and cost-effective diagnostic marker for assessing the severity of liver cirrhosis.

Keywords: CLD, Serum Uric acid, Child Pugh score, cirrhosis.

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Corresponding Author

Dr Manomenane M

Postgraduate, Department of Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India