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Category: Volume 09 Issue 12 December 2021
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Title: Clinicopathological Profile and Treatment Outcomes of Ameloblastoma- A Single Institution Experience

Authors: Dr Anila. K.R., DNB (Pathology), Dr Lakshmi Rajagopal, MD (Pathology), Dr Sindhu Nair P, DNB (Pathology) , Dr Thara Somanathan, MD (Pathology), Dr Shaji Thomas, MCh, Dr Venugopal M, MD

 DOI: https://dx.doi.org/10.18535/jmscr/v9i12.27

Abstract

Introduction: Ameloblastoma is a benign slow growing tumour of odontogenic origin. How-ever, they are locally aggressive and can cause severe deformities of face. Surgery with adequate margins is the standard treatment.

Objective: This study aims to report the clinicopathologic and follow-up details of patients with ameloblastoma treated at a tertiary care centre.

Materials and Methods: This was a retrospective study where-in archived data of patients histologically diagnosed with ameloblastoma between January 2010 and December 2020 at our centre were retrieved. Information on demographic details, clinicopathologic features, treatment modality, follow‑up period, and recurrence were obtained. This study had approval of the institutional review board of our institute.

Results: A total of twenty-one patients were included in this study. Male preponderance was noted. Age predisposition was seen in the fourth decade. Most common site of involvement was posterior aspect of mandible. Most common histologic sub-type was follicular type. Radical surgery was the treatment done in most of the cases due to large size of tumour. Recurrences were noted as late as after 48 years of initial surgery.

Conclusion: Ameloblastoma though benign can attain huge sizes requiring radical surgery. Recurrences can occur many years after initial diagnosis, hence patients need to be kept on follow-up for long durations, preferably lifelong.

Keywords: Ameloblastoma, mandible, clinicopathologic features, recurrence.

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Corresponding Author

Dr Anila.KR

Associate Professor, Department of Pathology, Regional Cancer Centre, Thiruvananthapuram,

Kerala-695011,India