Details
Category: Volume 09 Issue 05 May 2021
Hits: 935

Title: Clinicopathological Study of Malignant Melanoma at Tertiary Care Centre- SMS Medical Collage, Jaipur

Authors: Sharma Priyanka, Saini Sunita, Gupta Karuna

 DOI: https://dx.doi.org/10.18535/jmscr/v9i5.06

Abstract

Introduction: Malignant melanoma is a type of skin cancer which is arises from the pigment-producing cells - melanocytes.  Malignant Melanomas typically occur in the skin but rarely occur in the mouth, intestines or eye (uveal melanoma). Also may occur anywhere on the body. Symptoms of malignant melanoma include a new, unusual growth or a change in an pre-existing mole. Treatment may involve surgical excision, radiation, medication or in some cases, chemotherapy.

Objectives: To document the pattern of clinico-pathological spectrum of malignant melanoma cases at SMS Medical college,  Jaipur.

Methods: The present study was a retrospective study conducted in SMS Medical college, department of pathology, Jaipur between 2013 to 2019.  During this period total 90 cases received and diagnosed on biopsy.

Results: We received 90 cases in our department with age range from 10 to 86 years.  M: F ratio was 1.2:1 with male predominance. Most common age group is 51-60 year. In our study melanoma are predominantly non cutaneous origin (53) like rectum followed by anal canal, nasal-sinonasal, oral cavity and lymph node, followed by cutaneous melanoma (37).  Majority of histologic subtype of melanoma are nodular melanoma 17 (45.9%) followed superficial spreading melanoma 13(35.1) then acrolantigeeous 7(18.9). Half (50%) of the excisional biopsies were at Clark’s level III.

Conclusion: Malignant melanoma is aggressive tumor, more common in male then female. Nodular melanoma and superficial spreading was commonest histologic type malignant melanoma in our population.

Keyword: malignant melanoma, nodular, Clark’s level.

References

  1. Hui SK, Lau KH, Leung CY, Tang WYM, Chong LY, Lo KK. Cutaneous melanoma: clinical features of 32 Hong Kong Chinese patients. Hong Kong J Dermatol Venereol.  2005; 13:130-40.
  2. Sharma K, Mohanti BK, Rath GK. Malignant melanoma: A retrospective series from a regional cancer center in India. J Cancer Res Ther 2009; 5:173-80.  
  3. Lens MB, Dawes M. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br J Dermatol 2004; 150:179-85.  
  4. Wu E, Golitz LE. Primary noncutaneous melanoma. Clin Lab Med 2000; 20:731-44.
  5. Ali Z, Yousaf N, Larkin J. Melanoma epidemiology, biology and prognosis. EJC Suppl 2013; 11:81-91. 
  6. Mukhopadhyay S, Ghosh S, Siddhartha D, Mitra PK. A clinicopathological study of malignant melanoma with special reference to atypical presentation. Indian J Pathol Microbiol 2008; 51:485-8.
  7. Pappo AS. Melanoma in children and adolescents. Eur J Cancer 2003; 39:2651-61. 
  8. Thapa S, Ghosh A, Ghartimagar D, Prasad T, Narasimhan R, Talwar O, et al. Clinicopathological study of malignant melanoma at tertiary care centre. JNMA J Nepal Med Assoc 2017; 56:132-6.
  9. Wanebo HJ, Cooper PH, Young DV, Harpole DH, Kaiser DL. Prognostic factors in head and neck melanoma. Effect of lesion location. Cancer 1988; 62:831-7.
  10. Castel T, Baradad M, Castro J, Mascaró JM, García-Valdecasas JC, Grande L, et al. Primary malignant melanoma of the skin. Retrospective study of 375 cases. Clinical aspects and histology. Med Clin (Barc) 1990; 94:246-9.
  11. Chang JW. Cutaneous melanoma: Taiwan experience and literature review. Chang Gung Med J 2010; 33:602-12.
  1. Chopra A, Walia RL, Gupta S, Sethi PS, Begga HK. Nodular malignant melanoma-secondary to carcinoma rectum. Indian J Dermatol Venerol Leprol 1997; 63:327-9
  2. Radhika K, Prayaga AK, Sundaram C. A clinicopathologic study of malignant melanoma based on cytomorphology. Indian J Cancer 2016; 53:199-203.
  3. 14-Tjarta A, Kanoko M, Ueda M, Hamzah M, Cipto H, lchihashi M, et al. Rare case of melanoma studied for its histopathological features in Indonesia. Med J Indones 2000; 9:93-9
  4. Kumar V, Vishnoi JR, Kori CG, Gupta S, Misra S, Akhtar N, et al. Primary malignant melanoma of oral cavity: A tertiary care center experience. Natl J Maxillofac Surg 2015;6:167-71.
  5. Vayer A, Lefor AT. Cutaneous melanoma in African-Americans. South Med J 1993; 86:181-2
  6. Prasad ML, Busam KJ, Patel SG, Hoshaw-Woodard S, Shah JP, Huvos AG, et al. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 2003; 127:997-1002
  7. Padhye A, D'souza J. Oral malignant melanoma: A silent killer? J Indian Soc Periodontol 2011; 15:425-8
  8. Buissin D, Sterle A, Schmiegelow P, Wassenberg D, Ambe PC. Primary anorectal malignant melanoma: A rare but aggressive tumor: Report of a case. World J Surg Oncol 2015; 13:12
  9. Tariq MU, Ud Din N, Ud Din NF, Fatima S, Ahmad Z. Malignant melanoma of anorectal region: A clinicopathologic study of 61 cases. Ann Diagn Pathol 2014; 18:275-81.
  10. Ali Z, Yousaf N, Larkin J. Melanoma epidemiology, biology and prognosis. EJC Suppl 2013; 11:81-91.
  11. Heinzelmann-Schwarz VA, Nixdorf S, Valadan M, Diczbalis M, Olivier J, Otton G, et al. A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker. Int J Mol Med 2014; 33:784-94.
  12. Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol 2008; 35:433-44.  
  13. Prieto VG, Shea CR. Use of immunohistochemistry in melanocytic lesions. J Cutan Pathol 2008; 35 Suppl 2:1-0
  14. Compton LA, Murphy GF, Lian CG. Diagnostic immunohistochemistry in cutaneous neoplasia: An update. Dermatopathology (Basel) 2015; 2:15-42.
  15. Kuno Y, Ishihara K, Yamazaki N, Mukai K. Clinical and pathological features of cutaneous malignant melanoma: A retrospective analysis of 124 Japanese patients. Jpn J Clin Oncol 1996; 26:144-51.

Corresponding Author

Saini Sunita

Assistant Professor, Department of Pathology, Govt SK Medical Collage, Sikar