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Category: Volume 09 Issue 05 May 2021
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Title: A Study of Hormone Receptor Status in Breast Carcinoma and Their Histopathological Correlation

Authors: Dr Hemraj Bhardwaj, Dr Manish Khandelwal, Dr Siddharth Mittal, Dr Rakesh Kumar Sharma

 DOI: https://dx.doi.org/10.18535/jmscr/v9i5.05

Abstract

Introduction: Hormone receptors ER, PR, and Her2/neu status are now widely accepted as a prognostic marker and decide therapeutic modalities in breast carcinoma. The study aimed to analyze receptor status in breast carcinoma with histopathological characteristics of the tumor.

Purpose: To correlate the expression of prognostic factors such as patients' age, menopause, tumor size, number of lymph nodes, and histological grading with oestrogen, progesterone, and He2/ neu receptor status.

Material and Methods: In this study, 71 specimens of breast carcinoma after modified radical mastectomy, simple mastectomy, and lumpectomy were sent to the pathology department for immunohistochemical and histopathological examination to know the hormonal status well as histopathological characteristics.

Result: Seventy-one breast carcinoma specimen reports were received from the pathology department after immunohistochemical testing of ER, PR, and Her2/neu. The study showed only 39.43% cases were ER+ PR+, 15.49% cases were ER+, PR+ and Her2/neu+. 9.85% of cases were Her2/neu +, 5.63% cases ER+, and29.57% cases were ER-/ PR-/ Her2/neu negative (triple-negative).

According to this study's data, a statistically significant correlation of ER, PR, and Her2/neu was found with menopausal status, tumor size, number of lymph nodes, and tumor grade.

Conclusion: ER, PR, and Her2/ neu receptor status are critical predictor factors in cases of carcinoma of the breast, which necessitates the routine evaluation of hormonal receptor status for better management of the disease.

Keywords: Breast carcinoma, Oestrogen receptor, Progesterone receptor, Her2/neu, Menopause status, Lymph node involvement.

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Corresponding Author

Dr Rakesh Kumar Sharma

Senior Professor, Department of Surgery, Government Medical College - Kota, Rajasthan, India