Title: Tuberculosis and Guillian Barre Syndrome – A Rare Presentation of AMAN Variant
Authors: Urvashi Khan, Anil Kumar, Gauresh Singh, Ashok Kumar
DOI: https://dx.doi.org/10.18535/jmscr/v9i1.34
Abstract
Background
A 57-year female resident of U.P. presented with acute-onset quadriparesis that had developed during last 5 days along with breathlessness. After extensive clinical, laboratory and radiological evaluation, the patient was diagnosed with an acute motor axonal neuropathy (AMAN) variant of Guillain-Barre Syndrome (GBS). Treatment was given as per the protocol, simultaneously diagnosed to have tubercular meningitis for which first-line Anti-Tubercular Therapy was administered. During the follow-up at 6 months, the patient was asymptomatic, she had no residual weakness and could walk without support, and tuberculosis had resolved. Many infectious agents have been known to trigger GBS, but only a few cases of GBS and Tuberculosis have been reported. This association needs to be evaluated and must be kept in mind in TB prevalent nations
References
- Yuki N, Hartung HP, N Engl J Med. 2012 Jun 14;366(24):2294-304.
- Neurological complications of tuberculosis: some unusual manifestations. Kocen RS, Parsons M Q J Med. 1970 Jan; 39(153):17-30.
- Hughes RA, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barre syndrome. Cochrane Database Syst Rev.2014; CD002063.
- Canham EM, Iseman MD. Guillain-Barre syndrome related to pulmonary tuberculosis. Ann Am Thorac Soc. 2014; 11:855-857.
- de la Torre RG, Moris G, Martinez DP, Montes IC. Guillain-Barre syndrome, tuberculosis and inflammatory bowel disease: A multiple association. Int Arch Med. 2010; 3:15.
- Soehardy Z, Yuhanisa A, Thein SS, Rohana AG, Fauzi AR, Norlinah MI, Hamidon BB, Rozaidi SW. AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis. Med J Malaysia. 2005; 60: 655-656.
- Taha AA, Tee KH. Guillain-Barre syndrome associated with pulmonary tuberculosis. BMJ Case Rep. 2012; 13:2012.
- Vyravanathan S, Senanayake N. Guillain-Barre syndrome associated with tuberculosis. Postgrad Med J. 1983; 59:516-517.
- Srikant Mohta, Manish Soneja, Surabhi vyas, Wasim Khot tuberculosis and Guillian Barre Syndrome: A Chance Association.