Title: The Effects of Zinc on Shortening the Duration of the Covid-19 Symptoms

Authors: Hassan Darwish, PhD, Lorna Schumann, PhD, Jesse Hernandez

 DOI: https://dx.doi.org/10.18535/jmscr/v8i11.57

Abstract

Background: The emergence and spread of Coronavirus Disease 2019 (COVID-19) brought about a public health crisis threatening the globe. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), epitomizes society's greatest health problem and cause of death. Until a vaccine is developed, controlling the spread and supportive medications are essential. Zinc (Zn) is one of the supportive treatments that have significant and implicit antiviral characteristics that are appreciated in the treatment of the common cold and enhancing the immune system.

Objectives: To evaluate the connection between daily dosage of zinc tablets/lozenges and the duration of colds in patients.

Methods: Ovid MEDLINE was examined utilizing the free search terminologies “zinc and lozenges” that produced over 60 research articles. Findings from the zinc trials were analyzed using, P-values together with the Fisher method and combining the survey outcomes through the RevMan ©program.

Results: High-dose zinc acetate (greater than 75 mg) tests provide a decline in the duration of colds, and there is “heterogeneity” observed between the tests. 

Conclusions: Zinc lozenges can potentially reduce the duration of symptoms of the coronavirus when consumed within a day on the onset.

Keywords: Covid-19, Zinc (Zn), SARS-CoV-2

References

  1. Adhikari, D. D., & Das, S. (2016). Role of Zinc Supplementation in the Outcome of Repeated Acute Respiratory Infections in Indian Children: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Research Journal of Pharmacy and Technology9(4), 457-458.
  2. Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, S. C., & Di Napoli, R. (2020). Features, evaluation and treatment coronavirus (COVID-19). In Statpearls [internet]. StatPearls Publishing.
  3. Jackson, J. L., Lesho, E., & Peterson, C. (2020). Zinc and the common cold: a meta-analysis revisited—the Journal of Nutrition130(5), 1512S-1515S.
  4. Johnstone, J., Roth, D. E., Guyatt, G., & Loeb, M. (2015). Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. Cmaj184(10), E551-E561.
  5. Kumar, A., Kubota, Y., Chernov, M., &Kasuya, H. (2020). Potential Role of Zinc Supplementation in Prophylaxis and Treatment of COVID-19. Medical Hypotheses, 109848.
  6. Mousavizadeh, L., &Ghasemi, S. (2020). Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection.
  7. Nair, B. T., Bhunia, R., & Sharma, K. K. (2017). Role of zinc supplementation in acute respiratory tract infections in children aged 2 to 60 months. International Journal of Contemporary Pediatrics4(5), 1758-62.
  8. Rahman, M. T., & Idid, S. Z. (2020). Can Zn Be a Critical Element in COVID-19 Treatment? Biological Trace Element Research, 1-9.
  9. Skalny, A. V., Rink, L., Ajsuvakova, O. P., Aschner, M., Gritsenko, V. A., Alekseenko, S. I., ... &Tsatsakis, A. (2020). Zinc and respiratory tract infections: Perspectives for COVID‑19. International Journal of Molecular Medicine46(1), 17-26.
  10. Suara, R. O., & Crowe, J. E. (2016). Effect of zinc salts on respiratory syncytial virus replication. Antimicrobial agents and chemotherapy48(3), 783-790.
  11. Turner, R. B. (2016). The treatment of rhinovirus infections: progress and potential. Antiviral Research49(1), 1-14.
  12. Velthuis, A. J., Worm, S. H., Sims. (2016). Zn2+ inhibits coronavirus, and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS pathogens6(11), e1001176.
  13. info. 2020. Coronavirus Update (Live): 13,855,229 Cases and 589,947 Deaths From COVID-19 Virus Pandemic - Worldometer. [online] Available at: <https://www.worldometers.info/coronavirus/?utm_campaign=homeAdvegas1?> [Accessed 16 July 2020]
  14. teVelthuis, A., van den Worm, S., Sims, A., Baric, R., Snijder, E. and van Hemert, M., 2020. Zn2+ Inhibits Coronavirus And Arterivirus RNA Polymerase Activity In Vitro And Zinc Ionophores Block The Replication Of These Viruses In Cell Culture.

Corresponding Author

Hassan Darwish, PhD

Berkeley Diabetes &Botanical Research Institute, Laguna Beach, California, USA