Title: Abdominal Tuberculosis and value of CA 125 in diagnosis and completion of treatment- A Case Report
Authors: Dr Jayesh G. Kalbhande, Dr. Vicky Kuldeep
DOI: https://dx.doi.org/10.18535/jmscr/v8i4.10
Abstract
Tuberculosis is a common differential diagnosis in a case of ascites in Asian countries. A conclusive evidence of tuberculosis in form microscopy is important before started anti tubercular treatment. However, in many cases it is difficult or not possible to get microscopic evidence of tuberculosis. In these circumstances one has to rely on supportive evidence for diagnosis of tuberculosis. In our case of abdominal ascites caused by tuberculosis, TB PCR and TB culture was negative, although Histopathological finding were suggestive of tuberculosis as etiology. In addition CA 125 was found to be raised at the start of antitubercular treatment and it was normalized after completion of treatment. In this article we have reviewed publications on association of raised CA 125 with active cases of tuberculosis.
Keywords: CA 125, Abdominal tuberculosis.
References
- Bast RC, Feeney M. et al Reactivity of a monoclonal antibody with human ovarian carcinoma J Clin Invest, 1981, vol.68 (pg. 1331 - 37).
- Jacobs I1, Bast RC Jr. The CA 125 tumour-associated antigen: a review of the literature. Hum Reprod. 1989 Jan;4(1):1-12.
- Gurgan T, Zeyneloglu H, Urman B, Develioglu O, Yaraly A. Pelvic- peritoneal tuberculosis with elevated serum and peritoneal fuid CA125 levels: a report of two cases. Gynecol Obstet Invest 1993; 35: 60^61.
- B. Younossian, T. Rochat, L. Favre, J.P. Janssens, Ascites and highly elevated CA-125 levels in a case of peritoneal tuberculosis, Scand J. Infect. Dis., 38 (3) (2006), pp. 216-218.
- Simsek, M.C. Savas, A. Kadayifci, et al. Elevated serum CA 125 concentration in patients with tuberculous peritonitis: a case control study, Am. J. Gastroenterol., 92 (7) (1997), pp. 1174-1176.
- Yilmaz, F. Ece, B. Bayramgürler, E. Akkaya, R. Baran The value of Ca 125 in the evaluation of tuberculosis activity, Respir. Med., 95 (8) (2001), pp. 666-669.
- Aoki, O. Katoh, Y. Nakanishi, et al.A comparison study of IFN gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis, Respir. Med., 88 (2) (1994), pp. 139-143.
- Joseph D. Boss, Christopher T. Shah, Oladoyin Oluwole, and John N. Sheagren, “TB Peritonitis Mistaken for Ovarian Carcinomatosis Based on an Elevated CA-125,” Case Reports in Medicine, vol. 2012, Article ID 215293, 3 pages, 2012. https://doi.org/10.1155/2012/215293.