Title: Lipoprotein lipase levels in patients with Coronary Artery Disease with Type 2 Diabetes Mellitus
Authors: Dr Sathiyanarayanan Janakiraman, Dr Badrinath A.K, Dr Viswanathan K.N, Dr Suresh Babu.S, Dr Biju D.R
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.146
Abstract
Introduction: Diabetes mellitus is a common metabolic disease. Atherosclerosis being a risk factor is promoted by decreased LPL activity which leads to elevated TG levels and reduced high density lipoprotein cholesterol (HDL-C), both risk factors for the development of coronary artery disease (CAD).
So we studied the Lipoprotein lipase levels in patients with Coronary Artery Disease and in patients with Type 2 Diabetes Mellitus and comparing it with non diabetic individuals.
Objective: To determine Lipoprotein lipase levels in patients with Coronary Artery Disease with Type 2 Diabetes Mellitus.
Methodology: We conducted a hospital based comparative cross sectional study by dividing the patients into three groups. We compared the lipoprotein lipase levels in controls and in patients with diabetes mellitus and coronary artery disease.
Results: The mean lipoprotein lipase levels in controls were 46.2 but in patients with diabetes mellitus the mean lipoprotein lipase levels were reduced to 27.5 and in patients with diabetes and coronary artery disease it was further reduced to 17.5 with p value <0.001 which is statistically significant.
Conclusion: Reduced levels of lipoprotein lipase levels were seen in patients with coronary artery disease establishing the possible role of lipoprotein lipase in the pathogenesis of atherosclerosis.
Keywords: Lipoprotein lipase level (LPL), Diabetes mellitus and coronary artery disease.
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