Title: Histopathological spectrum of lesions in Nephrectomy specimens in a tertiary care hospital in North India
Authors: Anu Gupta, Subhash Bhardwaj
DOI: https://dx.doi.org/10.18535/jmscr/v8i2.144
Abstract
Introduction: Nephrectomy is a surgical procedure done for various conditions like chronic pyelonephritis, calculi, malignancies, obstruction and injury etc. Histopathological spectrum of various lesions in nephrectomy spectrum were studied to assess the patterns and morphology of lesions and to observe variation if any from the conventional pattern.
Materials & Method: The study was conducted in the Department of Pathology GMC Jammu over a period of 3 years from Dec 2016 to Jan 2020. 55 nephrectomy specimens were received from the surgical Department of the Hospital.
Results: Out of 55 nephrectomy specimens. 44 (80%) were benign and 11(20%) were malignant. Age ranged from 1 year to 72 years with the maximum cases seen in 51-60 years of age. Maximum cases were of Chronic Pyelonephritis 29 (52.72%), some associated with calculi and others with hydronephrosis. Renal Cell Carcinoma constituted 6 cases (10.90%) out of 11 total malignant lesions. Wilm’s tumour was the commonest malignant tumour seen in children. Most common clinical presentation was flank pain followed by burning micturition and fever.
Conclusion: Benign lesions outnumber the malignant. Chronic Pyelonephritis was the most common histopathological diagnosis and Renal Cell Carcinoma was commonest among the malignant lesions.
Keywords: Nephrectomy, Chronic Pyelonephritis (CPN), Kidney, Histopathology, Renal Cell Carcinoma (RCC).
References
- Kumar V, K.A, Fausto N. Robbins and Cotran Pathologic Basis of Disease: 2005; 7: 956-962
- Aiman A, Singh K, Yasir M. Histopathological spectrum of lesions in nephrectomy specimens: A five-year experience in a tertiary care hospital. J Sci Soc 2013;40:148-54.
- Henriksen KJ, Meehan SM, Chang A. Nonneoplastic Kidney Diseases in Adult Tumor Nephrectomy and Nephroureterectomy Specimens: Common, Harmful, Yet Underappreciated. Archives of Pathology & Laboratory Medicine 2009; 133: 1012-1025.
- Rafique M. Nephrectomy: Indications, complications and mortality in 154 consecutive patients. J Pak Med Assoc 2007; 5: 35-8.
- Lathif F, Mubarak M, Kazi JI. Histopathological characteristics of adult renal tumours: a preliminary report. J Pak Med Assoc 2011; 61: 224-8.
- Badmus TA, Salako AA, Sansui AA et al. Adult nephrectomy: our experience at lle- lfe. Niger J Clin Pract 2008; 11(2): 121-6.
- Kathirvelu S, Rajvaithy A, KV, Kotasthane D. Histopathological spectrum of Nephrectomy specimen in a tertiary care centre: with an emphasis on Chronic Pyelonephritis. Annals of Pathology and Laboratory Medicine. 2017; 4(5): 573-578.
- Popat VC, Kumar MP, Udani D, Mundra MP, Vora DN, Porecha MM. A Study On Culprit Factors, Ultimately Demanding Nephrectomy. The Internet Journal of Urology. 2009; 7(1): 1-8.
- Thaker BD, Singh K.A Histopathological Review of Nephrectomy Specimens Received in a Tertiary Care Hospital-A Retrospective Study. Journal of Medical Science And clinical Research. 2017; 05(06): 23807-23810.
- Shaila, Nityananda B.S, Tamil Arasi. Spectrum of lesions in Nephrectomy Specimens in a Tertiary care Hospital. J Evo Med Den Sci. 2015; 4(73): 12714-12726.
- Goldblum J, Lamps L, McKenney J, Myers J. Rosai and Ackerman’sSurgical Pathology. Kidney: Tumour and Tumour like conditions; 2 (11): 1048-1058.
- El Malik EM, Memon SR, Ibrahim AL, Al Gizawi A, Ghali AM. Nephrectomy in Adults: Asir Hospital Experience. Saudi J Kidney Dis Transpl 1997;8:423-7.